Table 5 PK parameters of AA II in rats after oral administration of AF and HAF (mean ± SD, n = 6)

Dose

mg/kg

0.21

0.26

0.56

0.69

1.05

1.29

C _max

μg/L

590.5 ± 191.1

293.0 ± 55.2*

1137.1 ± 193.1

411.8 ± 104.2*

1518.0 ± 200.0

528.2 ± 62.4*

T_max

h

1.03 ± 0.18

0.81 ± 0.14

1.33 ± 0.21

0.81 ± 0.16

1.83 ± 0.29

0.93 ± 0.19

t _1/2z

h

4.98 ± 0.55

4.94 ± 0.61

5.06 ± 0.49

4.95 ± 0.53

5.16 ± 0.52

5.39 ± 0.48

AUC_(0-∞)

μg/L · h

3958.9 ± 1002.8

2716.2 ± 795.2*

7824.5 ± 1975.8

3874.5 ± 1201.6*

12709.2 ± 2964.7

5628.0 ± 1693.4*

V_z/F

L/kg

0.49 ± 0.06

0.55 ± 0.07

0.48 ± 0.05

0.49 ± 0.06

0.82 ± 0.09

0.72 ± 0.08

CL_z/F

L/h/kg

0.07 ± 0.02

0.08 ± 0.02

0.07 ± 0.02

0.07 ± 0.02

0.11 ± 0.03

0.09 ± 0.02