Compounds | EC50 for each mode of antiviral activity (μM)a
|
|---|
Protectionb
| Absorptionc
| Replicationd
| Directe
|
|---|
4 | > 25 | 11 ± 3 | > 25 | 7 ± 4 |
5 | > 25 | 12 ± 4 | > 25 | 10 ± 2 |
6 | > 25 | 5.0 ± 0.2 | > 25 | 2.6 ± 0.1 |
7 | > 25 | 11 ± 3 | > 25 | 7 ± 1 |
-
aEffective concentration inhibiting 50% of lysis plaques induced by HSV-1 at different modes of antiviral activity. Acyclovir was used as positive control with 100% inhibition of lysis plaques at a concentration of 3 μM
-
bVero cells were pretreated with compounds prior infection
-
cVero cells and viruses were incubated together with compounds during absorption period
-
dCompounds were added after absorption and during the replication period
-
eViruses were incubated directly with compounds prior infection of Vero cells
