Table 1 Instances where T&CM should be considered in guideline development

1. The potential for at least modest clinical benefit where there is a large burden of disease^a;

2. High quality traditional evidence about safety and effectiveness that address a continuing burden of disease;

3. Cost-effective interventions that address a continuing burden of disease^a;

4. The potential for catastrophic risks from the T&CM intervention or its alternative;

5. Unknown benefit from a T&CM intervention that is commonly used^a;

6. Inequalities of access or large unmet need;

7. High demand to integrate within conventional healthcare settings;

8. High costs relative to alternatives or vice versa;

9. Large system changes required for its introduction^a; and

10. Conflict in choices between individual and societal perspectives^a.