Fig. 6

Sinularin triggered DNA damage responses in HepG2 cells. HepG2 cells were treated with sinularin at 12.5, 25, and 50 μM for 24 h followed by western blotting to measure the DNA damage related proteins, phospho and non-phospho ATM, ATR, Chk1, Chk2, and H2A.X. GAPDH expressions were measured as internal controls to show equal protein loading. The data presented are representatives of three independent experiments with similar results