Fig. 4

Interaction between TKP and IR. a Docking analysis. The IR ectodomain monomer is shown in a schematic presentation. Individual domains are colored as follows: L1, blue; CR, pink; L2, green; fibronectin type III domain, orange. TKP is shown in an atomic sphere representation. b IR kinase activity assay. Various amounts of TKP were incubated with IR in the presence of ³²P-ATP and poly(Glu,Tyr). The radioactivity (dpm) incorporated into the precipitated poly(Glu,Tyr) was counted by a scintillation counter