Table 3 Antinociceptive effect of D. sissoo leave extract, morphine and reversal effect of naloxone in tail immersion test
From: Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice
Treatment | Dose (mg/kg) | Latency period (s) (% MPE) Pretreatment | 30 min | 60 min | 90 min | 120 min | |
|---|---|---|---|---|---|---|---|
Treatment without Naloxone | Control | 0.1 mL/mouse | 2.16 ± 0.23 | 2.48 ± 0.16 | 2.68 ± 0.19 | 2.92 ± 0.12 | 3.64 ± 0.14 |
Morphine | 5 | 2.03 ± 0.15 | 3.90 ± 0.18** (8.10) | 4.90 ± 0.18*** (12.81) | 5.40 ± 0.40** (14.51) | 5.46 ± 0.25***(11.12) | |
MEDS | 100 | 2.20 ± 0.20 | 3.30 ± 0.12 (4.68) | 3.73 ± 0.15* (6.08) | 4.37 ± 0.21 (8.50) | 5.36 ± 0.24***(10.51) | |
MEDS | 200 | 3.81 ± 0.18 | 3.72 ± 0.27* (7.10) | 4.58 ± 0.45*** (10.94) | 5.91 ± 0.68*** (17.49) | 6.02 ± 0.14***(14.53) | |
MEDS | 400 | 2.26 ± 0.09 | 4.02 ± 0.43** (8.80) | 4.76 ± 0.23*** (12.00) | 5.64 ± 0.37*** (15.92) | 5.90 ± 0.18***(13.81) | |
Treatment with Naloxone | NLX | 2 | 1.92 ± 0.13 | 2.28 ± 0.16 | 2.77 ± 0.15 | 2.53 ± 0.16 | 2.37 ± 0.18 |
NLX+ Control | 2 + 0.1 mL/mouse | 1.77 ± 0.10 | 2.09 ± 0.16 | 2.33 ± 0.14 | 2.18 ± 0.11 | 2.63 ± 0.11 | |
NLX+ Morphine | 2 + 5 | 2.08 ± 0.05 | 2.52 ± 0.13 (0.22) | 3.36 ± 0.18 (3.92) | 3.98 ± 0.37 (6.20) | 5.01 ± 0.30 (8.36) | |
NLX+ MEDS | 2 + 100 | 2.11 ± 0.14 | 2.60 ± 0.11 (0.68) | 3.29 ± 0.15 (3.52) | 3.84 ± 0.39 (5.38) | 4.82 ± 0.09 (7.21) | |
NLX+ MEDS | 2 + 200 | 3.59 ± 1.14 | 2.63 ± 0.18 (0.85) | 3.52 ± 0.29 (4.84) | 3.82 ± 0.37 (5.24) | 5.02 ± 0.13 (8.43) | |
NLX+ MEDS | 2 + 400 | 2.04 ± 0.07 | 2.68 ± 0.27 (1.14) | 3.56 ± 0.34 (5.09) | 4.21 ± 0.25 (7.56) | 5.16 ± 0.16 (9.29) | |