Fig. 4

Antiviral effect on the viral genome replication of DENV-2/NG during the post-treatment strategy. The cells were infected and subsequently treated with the compounds at concentrations from 0.8 to 200 μg/mL and compared with the untreated controls. a Effects of the compounds extracted from the M. Americana seeds. b Effects of the compounds extracted from the T. cymosa seeds. Statistically significant inhibitions are observed in the cultures treated with coumarin A (concentrations greater than 3.1 μg/mL) or treated with coumarin B, lupeol acetate, or voacangine (all of the concentrations evaluated here) (ANOVA-LSD, p < 0.05)