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Table 2 Webb’s fractional product of co-treatment of chemotherapy with viscum, TT and viscumTT

From: ViscumTT induces apoptosis and alters IAP expression in osteosarcoma in vitro and has synergistic action when combined with different chemotherapeutic drugs

 

TT

viscum

viscumTT

A

DOXO

0.1 + 20

0.1 + 30

0.1 + 40

0.1 + 1.5

0.1 + 2

0.1 + 2.5

0.1 + 1.5 + 20

0.1 + 2 + 30

0.1 + 2.5 + 40

*FP

1.39

1.37

1.32

1.22

1.07

1.11

1.06

1.32

1.26

VP16

0.5 + 20

0.5 + 30

0.5 + 40

0.5 + 1.5

0.5 + 2

0.5 + 2.5

0.5 + 1.5 + 20

0.5 + 2 + 30

0.5 + 2.5 + 40

*FP

3.20

2.48

1.73

2.44

1.86

1.72

2.00

1.79

1.27

4OOH

0.5 + 20

0.5 + 30

0.5 + 40

0.5 + 1.5

0.5 + 2

0.5 + 2.5

0.5 + 1.5 + 20

0.5 + 2 + 30

0.5 + 2.5 + 40

*FP

1.14

1.10

1.28

1.37

1.20

0.97

1.19

1.13

1.20

B

DOXO

0.05 + 20

0.05 + 30

0.05 + 40

0.05 + 1.5

0.05 + 2

0.05 + 2.5

0.05 + 1.5 + 20

0.05 + 2 + 30

0.05 + 2.5 + 40

*FP

0.83

0.82

0.82

0.72

0.84

0.85

0.80

0.89

0.83

VP16

0.5 + 20

0.5 + 30

0.5 + 40

0.5 + 1.5

0.5 + 2

0.5 + 2.5

0.5 + 1.5 + 20

0.5 + 2 + 30

0.5 + 2.5 + 40

*FP

0.99

1.00

0.94

0.85

0.89

1.01

0.85

0.84

0.93

4OOH

0.5 + 20

0.5 + 30

0.5 + 40

0.5 + 1.5

0.5 + 2

0.5 + 2.5

0.5 + 1.5 + 20

0.5 + 2 + 30

0.5 + 2.5 + 40

*FP

1.22

1.23

1.04

0.75

0.85

0,86

0.85

0.92

0.91

  1. Co-treatment of viscum (ng/mL), TT (μg/mL) and viscumTT with doxorubicin (Doxo (0.1 (A), 0.05 (B) μg/mL)), etoposide (VP16 (0.5 μg/mL)) and ifosfamide (4OOH (0.5 μg/mL)) led to synergistic or additive apoptosis induction in 143B (A) and Saos-2 (B) cells (*Fp > 1 = synergistic effect, *Fp = 1 = additive effect). Oleanolic acid (OA) and mistletoe lectin (ML) were used as marker substances for viscum and TT
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BMC Complementary Medicine and Therapies

ISSN: 2662-7671

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