Fig. 2
Inhibition potencies and selectivity of hMAO-A and hMAO-B by PCS benzopyrone constituents. The Table displays IC50s of BIO-A, PS, IPS, 6-PN, NBI, and PSD compared with standards deprenyl (DEP) and clorgyline (CLORG), with relative selectivity for isozymes A (RSA) and B (RSB), using a spectrophotometric assay. a hMAO-A and (b) hMAO-B confirmation of inhibition by the six benzopyrones compared to PCSEE, DEP, and solvents of ethanol (EOH) and DMSO using a luminescence assay. IC50 ± SEM is interpolated from two sigmoidal curves, and data points were presented as the mean ± SEM percentage isozyme activity of at least two independent experiments of n = 3. RSA and RSB are the ratio between high isozyme IC50 to the low IC50. Significances of differences between groups and control were determined using a one-way ANOVA followed by Dunnett’s multiple comparisons test. * p ≤ 0.05, **** p < 0.001