Treatment/Dose | Time in Sec (Tail Flick)/Response (%) | |||||
---|---|---|---|---|---|---|
15Â min | 30Â min | 45Â min | 60Â min | 75Â min | 90Â min | |
Control (2% Tween 80) | 0.79 ± 0.017 | 0.87 ± 0.033 | 0.99 ± 0.024 | 0.94 ± 0.036 | 0.87 ± 0.029 | 0.90 ± 0.048 |
Ism-1 25 mg 50 mg | 0.95 ± 1.12* (20.25%) | 1.07 ± 0.112* (22.98%) | 1.30 ± 0.131** (31.31%) | 1.33 ± 0.124** (41.48%) | 1.33 ± 0.163*** (52.87%) | 1.33 ± 0.138*** (47.77%) |
0.98 ± 1.20 (24.05%) | 1.11 ± 0.411* (27.58%) | 1.34 ± 0.161** (35.35%) | 1.37 ± 0.201** (45.74%) | 1.38 ± 0.206*** (58.62%) | 1.36 ± 0.218*** (51.11%) | |
Standard (M) | 1.20 ± 0.024 (48.14%) | 2.03 ± 0.066 (56.15%) | 3.89 ± 0.038 (75.06%) | 6.30 ± 0.054 (85.07%) | 4.40 ± 0.050 (80.22%) | 4.30 ± 0.074 (78.37%) |
N + 1 25 mg 50 mg | 0.93 ± 0.045 | 0.94 ± 0.043 | 1.10 ± 0.052 | 0.99 ± 0.052 | 0.90 ± 0.058 | 0.93 ± 0.096 |
0.89 ± 0.039 | 0.95 ± 0.068 | 1.50 ± 0.064 | 0.99 ± 0.047 | 0.89 ± 0.080 | 0.95 ± 0.089 | |
M + N | 0.80 ± 0.046 | 0.87 ± 0.037 | 0.94 ± 0.045 | 0.91 ± 0.033 | 0.91 ± 0.034 | 0.91 ± 0.045 |