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Fig. 4 | BMC Complementary and Alternative Medicine

Fig. 4

From: A candidate Chinese medicine preparation-Fructus Viticis Total Flavonoids inhibits stem-like characteristics of lung cancer stem-like cells

Fig. 4

FVTF inhibits self-renewal of LCSLCs. a, FVTF selectively inhibited the proliferation of LCSLCs in a concentration-dependent manner. b and c, FVTF significantly decrease the primary and secondary tumor sphere forming rates of LCSLCs. d, FVTF decreased expression level of the self-renewal related transcription factors Bmi1, Nanog and Oct4 in a concentration-dependent manner at 48 h. e, FVTF decreased the expression of stem cell markers CD 133 of LCSLCs in a concentration-dependent manner as analyzed by Flow cytometry analysis at 48 h. ISC: Isotype control, SFC: CD133+ sphere forming cells derived from NCI-H446 cells; F, FVTF decreased the expression of stem cell markers CD 44 and ALDH1 of LCSLCs in a concentration-dependent manner as analyzed by western blotting at 48 h

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