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Table 2 Mean percent activity of crude extracts on Onchocerca ochengi adult worms and mf in primary screens

From: Filaricidal activities on Onchocerca ochengi and Loa loa, toxicity and phytochemical screening of extracts of Tragia benthami and Piper umbellatum

Plant or control Extract code Concentration tested Activity on O. ochengi male (%) Activity on O. ochengi female (%) Activity on O. ochengi mf (%)
Tragia benthami TBLhex 500 μg/mL 100 91.25 75
TBLmc 500 μg/mL 100 87.5 100
TBLmet 500 μg/mL 100 56.25 100
TBRhex 500 μg/mL 100 100 100
TBRmc 500 μg/mL 100 93.75 100
TBRmet 500 μg/mL 100 12.5 100
Piper unbellatum PULhex 500 μg/mL 100 100 100
PULmc 500 μg/mL 100 100 100
PULmet 500 μg/mL 100 100 100
PURhex 500 μg/mL 100 100 100
PURmc 500 μg/mL 100 100 100
PURmet 500 μg/mL 100 100 100
PUShex 500 μg/mL 100 100 100
PUSmc 500 μg/mL 100 100 100
Negative control NA 2 % DMSO 0 0 0
Auranofin (Positive control) NA 10 μM 100 100 100
  1. TBL Tragia benthami leaves, TBR Tragia benthami roots, PUL Piper umbellatum leaves, PUR Piper umbellatum roots, PUS Piper umbellatum seeds, hex hexane, mc methylene chloride, met methanol, NA not applicable