Fig. 5

Effects of PF and MK-801 on high dose morphine-induced clonic seizure- like excitation. PF (100, 200, or 500 nmol, i.c.v.) was administered 15 min before injection of morphine (250 nmol, i.t.). MK-801 (14.8 pmol, i.t.) was injected 5 min before excitatory amino acid injection. Control mice received ACSF. The onset time a and total numbers of clonic seizure-like excitation episodes b induced by morphine injection was recorded for 60 min. Data represent mean ± S.E. (n = 12). ^*** p < 0.001 compared with the control group; ^# p < 0.05, ^### p < 0.001 compared with the MK-801 treated group, respectively