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Table 2 Effect of FXM and its fractions in hot plate test

From: Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies

Treatment Dose/route Mean latency time in seconds Increase in latency time (seconds) after various dosages (Mean ± SD)/Percent analgesia
   0 min 30 min 60 min 120 min
Saline 2 ml, i.p. 8.83 ± 0.75 10.33 ± 0.51 9.83 ± 0.40 9.50 ± 0.44
    7.03 ± 2.41e 4.65 ± 2.87h 3.03 ± 2.69i
FXM 100 mg/kg, p.o. 9.33 ± 0.51 13.00 ± 0.89 15.50 ± 0.54 17.00 ± 0.63
    17.61 ± 6.27c 29.80 ± 3.19e 37.10 ± 2.44cd
FXM 200 mg/kg, p.o. 9.66 ± 1.03 16.50 ± 0.54 21.33 ± 1.03 23.66 ± 1.03
    33.46 ± 4.41b 57.35 ± 4.72c 68.72 ± 5.71b
FXH 100 mg/kg, p.o. 9.50 ± 0.54 10.33 ± 0.51 12.00 ± 0.89 13.66 ± 0.51
    4.00 ± 3.59de 12.10 ± 5.78fgh 20.31 ± 1.77fgh
FXH 200 mg/kg, p.o. 9.50 ± 0.54 10.66 ± 0.51 13.66 ± 0.51 15.66 ± 0.51
    5.63 ± 3.56de 20.31 ± 1.77ef 30.00 ± 4.08def
FXC 100 mg/kg, p.o. 9.16 ± 0.75 12.33 ± 0.51 15.00 ± 0.89 18.00 ± 0.89
    15.13 ± 3.23cd 27.99 ± 3.46e 42.33 ± 4.83c
FXC 200 mg/kg, p.o. 9.00 ± 0.63 15.66 ± 0.51 18.66 ± 0.51 25.00 ± 0.89
    31.69 ± 3.14b 45.99 ± 3.89d 76.13 ± 4.49ab
FXE 100 mg/kg, p.o. 9.66 ± 0.51 12.00 ± 0.89 12.33 ± 0.51 13.33 ± 0.51
    11.46 ± 4.01cde 13.05 ± 3.72fgh 18.01 ± 2.37fgh
FXE 200 mg/kg, p.o. 9.66 ± 0.81 12.33 ± 0.51 14.66 ± 0.51 16.66 ± 0.89
    13.02 ± 3.81cd 24.54 ± 2.44e 34.39 ± 3.24cde
FXB 100 mg/kg, p.o. 9.33 ± 1.03 10.33 ± 0.72 12.33 ± 0.51 14.00 ± 0.89
    4.60 ± 2.11de 14.42 ± 2.43fg 22.53 ± 3.36fgh
FXB 200 mg/kg, p.o. 9.83 ± 0.75 11.16 ± 0.89 12.83 ± 0.51 15.00 ± 0.89
    5.63 ± 3.42de 10.59 ± 6.40gh 25.53 ± 5.14efg
FXA 100 mg/kg, p.o. 9.50 ± 0.54 9.66 ± 0.51 11.66 ± 0.51 12.33 ± 0.51
    3.75 ± 0.65c 10.47 ± 4.55gh 13.77 ± 3.41h
FXA 200 mg/kg, p.o. 9.00 ± 0.89 10.33 ± 0.51 12.00 ± 0.89 13.66 ± 1.03
    6.13 ± 4.21cde 14.30 ± 1.61fg 22.25 ± 2.68fgh
Diclofenac sodium 10 mg/kg, i.p. 9.83 ± 0.75 21.66 ± 0.51 26.66 ± 1.51 26.66 ± 1.62
    58.69 ± 1.45a 83.51 ± 4.21a 83.39 ± 5.07a
Morphine 10 mg/kg, i.p. 9.33 ± 0.51 20.16 ± 0.75 23.66 ± 0.81 23.00 ± 0.89
    52.34 ± 4.59a 69.36 ± 3.84b 66.03 ± 5.13b
  1. FXM F. xanthoxyloides methanol extract, FXH F. xanthoxyloides n-hexanefraction, FXC F. xanthoxyloides chloroform fraction, FXE F. xanthoxyloides ethyl acetate fraction, FXB F. xanthoxyloides n-butanol fraction, FXA F. xanthoxyloides residual aqueous fraction. Data values shown represent mean ± SD (n = 6). One-way ANOVA followed by Tukey’s HSD multiple comparison tests. Percentage analgesia is shown in brackets. Different alphabets in each column indicate difference at P <0.05