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Table 1 Effects of asiatic acid on hemodynamic status and metabolic parameters

From: Asiatic acid attenuates renin-angiotensin system activation and improves vascular function in high-carbohydrate, high-fat diet fed rats

Parameters

Normal control

MS

MS + AA

SP (mmHg)

115.7 ± 2.1

149.2 ± 4.2*

130.2 ± 2.6*,**

DP (mmHg)

75.2 ± 1.9

100.9 ± 2*

88.5 ± 1.3*,**

MAP (mmHg)

89.2 ± 1.8

117.8 ± 2.5*

103.8 ± 1.7*,**

HR (beats/min)

351.3 ± 12.7

418.5 ± 11.4*

361.8 ± 10.1**

HBF (mL/min/100 g tissue)

7 ± 0.3

4.1 ± 0.1*

6.1 ± 0.3**

HVR (mmHg/mL/min/100 g tissue)

13.1 ± 0.5

29 ± 1.2*

17.6 ± 0.9*,**

Fasting blood glucose (mg/dL)

86.9 ± 2.5

117.6 ± 1.7*

90.6 ± 1.5**

Fasting serum insulin (ng/mL)

0.4 ± 0.1

4.7 ± 0.5*

1.9 ± 0.3*,**

HOMAR-IR index

1.9 ± 0.2

31.2 ± 3.3*

9.9 ± 1.5**

Cholesterol level (mg/dL)

52.2 ± 1.8

82.3 ± 2.3*

57.3 ± 2.4*,**

Triglyceride level (mg/dL)

28.6 ± 3.6

80.7 ± 5.8*

31.7 ± 1.7**

HDL-C level (mg/dL)

42.5 ± 1.6

18.2 ± 1.8*

31.2 ± 2.1*,**

  1. SP systolic blood pressure, DP diastolic blood pressure, MAP mean arterial pressure, HR heart rate, HBF hindlimb blood flow, HVR hindlimb vascular resistance, HOMA-IR, homeostasis model assessment of insulin resistance, HDL-C high density lipoprotein cholesterol. Values are mean ± SEM (n = 14 for each group); *p < 0.05 compared to the control group; **p < 0.05 compared to the MS group