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Table 3 Characteristics of included studies

From: Evidence-based review of oral traditional Chinese medicine compound recipe administration for treating weight drop-induced experimental traumatic brain injury

Study Animal Species Treatment Groups(Drug/Dose) Anaesthetic used Time of administration Main Outcomes Quality Score
Long 2001 [1] Mixed Kunming mice Naozhenning Granule(13.33 g/kg) Naochuangning (9.08 g/kg) Naochuangning (18.16 g/kg) Naochuangning (36.33 g/kg) Unknown 7 days before injury Daily for 10 days Cerebral edema BBB permeability 2
Zhang 2002 [3] SD rats Brain injury compound decoction (unknown) Ether 3 days before injury Daily for 10 days Independent activity Cognitive performance 4
Wang 2003 [4] Mixed Wistar rats Naozhenning Granule(13.13 g/kg) Naochuangning (9.15 g/kg) Naochuangning(19.10 g/kg) Naochuangning (38.10 g/kg) Pentobarbital After injury Daily for 14 days Memory performance Endothelia content 4
Zhang 2004 [5] SD rats Tongfujiannao Oral Liquid(7.5 g/kg) Tongfujiannao Oral Liquid(3.125 g/kg) Unknown After injury Daily for 3 days Brain water content MDA\SOD content(Brain) \LPS content(Plasma) Histopathological 3
Cui 2005a [6] Male SD rats Naoshuning(15 g/kg) chloral hydrate 3 days before injury Twice for 4 days Neurological function Histopathological Brain water conte 3
Cui 2005b [7] Male SD rats Naoshuning(15 g/kg) chloral hydrate 3 days before injury Twice for 4 days BBB permeability Brain water content MMP-9 3
Yu 2005 [8] Kunming mice Shenqi Extraction (0.28 g/kg) Shenqi Extraction (0.14 g/kg) Shenqi Extraction (0.07 g/kg) Ether 3 days before injury Daily for 3 days BBB permeability Brain water content TNF-α(Brain)\ ET content(Serum) 4
Zhou 2007 [9] Mixed SD rats Huayu capsule (1.030 g/kg) Huayu capsule (0.515 g/kg) Huayu capsule (0.258 g/kg) chloral hydrate After injury Daily for 7 days Nerve-muscle catching capability. Histopathological 3
Cui 2008a [10] Male SD rats Naoshuning(7.5 g/kg) chloral hydrate 3 days before injury Twice for 4 days Brain water content BBB permeability AQP-4 content 3
Cui 2008b [11] Male SD rats Naoshuning(7.5 g/kg) Unknown 3 days before injury Twice for 4 days BBB permeability Histopathological cerebral microvascular density 3
Miao 2008 [12] Male Wistar rats Brain Compound decoction(10 g/kg) Pentobarbital Immediately after injury Twice for 7 days Na+-K+-ATP Ca2+-ATP 5
Cui 2009a [13] SD rats Naoshuning(7.5 g/kg) Unknown 3 days before injury Daily for 3 days Histopathological (HE statin) Edema volume Brain water content 3
Cui 2009b [14] Male SD rats Naoshuning(7.5 g/kg) Unknown 3 days before injury Twice for 8 days MMP-2/9 content Brain water content EB content 3
Xiong 2009 [15] SD rats Quyu Tongfu decoction(10 ml/kg) compound Huangjinxiang extraction liquid(10 ml/kg) Pentobarbital 20 min after injury Daily for 24 h AQP- 4 content 5
Xie 2010 [16] Mixed SD rats Angong Niuhuang Pill(0.6 g/kg) chloral hydrate 12 h before injury Twice for 60 h Synaptic density BBB permeability Cerebral edema 3
Xu 2010 [17] Mixed SD rats Angong Niuhuang Pill (0.121 g/2 ml) Pentobarbital After injury Daily for 12 days ApoE content (Brain and CSF) 4
Miao 2011 [18] Male Wistar rats Brain Compound decoction(10 g/kg) Pentobarbital Immediately after injury Twice for 7 days NO\nNOS(Brain) Brain water content Histopathological 5
Zhang 2011 [19] Wistar rats Sanhuang Xiexin Decoction(10 g/kg) chloral hydrate Immediately after injury Daily for 72 h NF-κB\IL- 6 content 3
Wang 2012a [20] SD rats Longxuejie capsule (2.6 mg/g/d) Unknown after injury Daily for 5d NO\TNF-α content (serum) 3
Wang 2012b [21] Male SD rats modified “Shengyu”decoction 4.0 mL/200 g/d Unknown 6 h after injury Twice for 72 h Histopathological caspase-3 activity 3
Zhao 2012 [22] Mixed SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury Daily for 10d CGRP content (Plasma) 3
Zhou 2012 [23] SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury Daily for 10d NPY content (serum) 3
Fan 2013a [24] SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury Daily for 10d S100B content (serum) 3
Fan 2013b [25] SD rats JiannaoYizhi capsules(6.0 g/kg/d) chloral hydrate 24 h after injury Daily for 10d NSE content (serum) 3
Zhao 2014 [26] Male SD rats modified “Shengyu”decoction 0.5 mL/200 g modified “Shengyu”decoction 1.0 mL/200 g modified “Shengyu”decoction 2.0 mL/200 g chloral hydrate 6 h after injury Daily for 7d Neurological function Brain water content Histopathological Lesion volume TNF-α\ IL-1\IL-6\IL-10 content (brain) 6
  1. Note: BBB Blood–brain-barrier, MMP-9 matrix metalloprotein 9, TNF-α tumor necrosis factor-α, IL-1 interleukin-1, IL-6 interleukin-6, IL-10 interleukin-10, NSE 2-phospho-D-glycerate hydrolase, NPY Neuropeptide Y, CGRP Calcitonin Gene Related Peptide, SOD superoxidedismutase, MDA malondialdehyde, NO Nitrogen monoxide, SD Sprague Dawley.-