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Table 7 Effect of water, butanol and chloroform fractions on body weight of P. berghei infected Swiss albino mice

From: Evaluation of the antiplasmodial properties of selected plants in southern Ethiopia

Fraction type

Dose mg/kg/day

Body weight (M ± SEM)

% of change (M ± SEM)

P value

D0

D4

Water

100

26.20 ± 0.44

27.06 ± 0.46

3.28 ± 0.24*a

0.027

200

28.14 ± 0.39

29.82 ± 0.48

6.10 ± 0.30*a

0.018

400

28.80 ± 0.17

31.28 ± 0.13

9.03 ± 0.32*a

0.000

n-Butanol

100

27.64 ± 0.09

28.80 ± 0.20

3.19 ± 0.51*a

0.033

200

27.96 ± 0.06

29.38 ± 0.10

6.23 ± 0.48*a

0.026

400

28.52 ± 0. 13

30.40 ± 0.21

6.59 ± 0.58*a

0.000

Chloroform

100

26.34 ± 0.25

26.94 ± 0.31

2.26 ± 0.32

0.080

200

27.12 ± 0.31

28.04 ± 0.39

3.67 ± 0.46

0.072

400

29.08 ± 0.27

30.58 ± 0.4

5.14 ± 0 .42*a

0.031

NC

0

26.80 ± 0.33

25.86 ± 0.27

−2.41 ± 0. .92

 

PC

10

27.38 ± 0.51

28.94 ± 0.62

5.00.95 ± 0.71

  1. Values are expressed as M ± SEM; n = 5
  2. NC negative control (0.2 mL of dH2O), PC positive control (Chloroquine)
  3. *P < 0.05
  4. acompared to negative control