Skip to main content

Advertisement

Table 1 Effects of S. crispus extracts on the number of crypts per focus on AOM-induced ACF in rat colons

From: Evaluation of chemopreventive potential of Strobilanthes crispus against colon cancer formation in vitro and in vivo

Group Number of foci ACF
1 crypt 2 crypts 3 crypts 4 crypts >5 crypts Total Inhibition %
Cancer control group (AOM) 26 ± 7.15 36 ± 8.4 31 ± 4.4 25 ± 1.4 32 ± 7.3 150 ± 21.0 0
AOM + 5-FU 10 ± 2.1** 9 ± 2.3** 9 ± 2.6** 5 ± 1.5** 8 ± 2.6** 41 ± 9.6** 72.6 %
AOM+ S. crispus (250 mg/kg) 4 ± 1.4** 11 ± 2.3** 13 ± 0.5** 8 ± 2.5** 8 ± 2.4** 44 ± 4.6** 70.6 %
AOM+ S. crispus (500 mg/kg) 8 ± 0.5** 10 ± 2.7** 11 ± 2.1** 8 ± 1.2** 6 ± 1.2** 43 ± 2** 71.3 %
  1. All values are expressed as mean ± SEM. **Significant difference at p < 0.01 (ANOVA, Tukey’s post hoc). 5-FU 5-Fluorouracil, ACF aberrant crypt foci, AOM azoxymethane