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Table 6 Evaluation of the protective effect of the plants extracts on the biochemical parameters of liver in CCl4-induced hepatic damage in mice

From: Impact of phenolic composition on hepatoprotective and antioxidant effects of four desert medicinal plants

  Control CCl4 control F. indica Z hamiense C. procera S. imbricata
5 mg/kg 10 mg/kg 250 mg/kg 500 mg/kg 100 mg/kg 200 mg/kg 250mg/kg 500mg/kg
ALT (U/L) 290.1 ± 54.0 1736.7 ± 161.2a 2166.7 ± 157.8b 1064.0 ± 264.9c 1416.7 ± 105.8 950.3 ± 84.4 1054.3 ± 117.5c 801.7 ± 76.0c 1135.0 ± 127.9c 476.7 ± 151.0c
AST(U/L) 850.0 ± 63.2 1736.7 ± 215.1a 1310.0 ± 181.5b 926.2 ± 258.6c 756.7 ± 128.6c 783.3 ± 80.1c 787.8 ± 69.6c 922.7 ± 65.4c 647.5 ± 62.8c 530.0 ± 120.8c
ALP(U/L) 180.0 ± 20.3 150.2 ± 55.7 125.0 ± 22.5 124.3 ± 17.4 106.7 ± 24.0 113.3 ± 29.1 51.8 ± 4.7 59.5 ± 6.1 c 110.0 ± 14.7 63.3 ± 8.8
CAT kU/g protein 462.0 ± 21.1 241.3 ± 11.4a 307.2 ± 9.2c 392.200 ± 9.4c 225.1 ± 10.5 259.1 ± 5.1 324.7 ± 25.8b 335.0 ± 25.0c 356.2 ± 24.1c 374.9 ± 10.7c
GSH-Px U/g protein 1.3 ± 0.1 0.85 ± 0.06a 1.1 ± 0.2 1.2 ± 0.2 0.72 ± 0.1 0.94 ± 0.2 1.4 ± 0.06 1.4 ± 0.06 0.91 ± 0.06 1.39 ± 0.19b
SOD μg/g protein 34.6 ± 2.9 22.0 ± 2.4a 26.7 ± 1.8 32.9 ± 1.6c 21.1 ± 1.7 23.6 ± 1.5 22.7 ± 1.2 31.5 ± 1.1b 24.8 ± 0.5 26.4 ± 1.3
TBARS (nmol/g prot.) 0.049 ± 0.02 0.54 ± 0.20a 0.12 ± 0.09c 0.085 ± 0.05c 0.42 ± 0.2 0.36 ± 0.4 0.14 ± 0.07c 0.06 ± 0.01c 0.11 ± 0.05c 0.071 ± 0.02c
  1. aSignificant difference (p < 0.01) compared to control group; bSignificant difference (p < 0.05) compared to CCl4 treated group; cSignificant difference (p < 0.01) compared to CCl4 treated group