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Table 3 Effect of ethanolic extract of c. roseus on some biochemical parameter on rats

From: Anti-diabetic potential of Catharanthus roseus Linn. and its effect on the glucose transport gene (GLUT-2 and GLUT-4) in streptozotocin induced diabetic wistar rats

Dose mg/kg GLU mg/dl CHOL mg/dl CRE Umol/L ALP IU/L ALT IU/L AST IU/L GST IU/L BUN mg/dl
Normal Control Group 98.9 ± 2.28 59.12 ± 5.08 107.24 ± 4.08 102.4 ± 3.81 56.82 ± 5.04 87.28 ± 5.83 0.59 ± 0.05 38.40 ± 2.36
Diabetic Control Group 256.32 ± 8.64 117.34 ± 2.20 196.74 ± 2.84 286.21 ± 5.34 134.20 ± 7.41 37.43 ± 4.59 0.45 ± 0.06 116.2 ± 1.24
Treated with 100 mg/kg C. roseus 189.42 ± 11.2* 92.49 ± 7.17* 168.26 ± 6.23* 185.36 ± 4.32* 98.64 ± 8.80* 116.16 ± 4.51* 0.44 ± 0.07 86.26 ± 2.49*
Treated with 200 mg/kg C. roseus 153.34 ± 6.72** 85.43 ± 6.61** 132.41 ± 6.31** 150.42 ± 4.78** 81.38 ± 4.86** 125.29 ± 5.09 0.44 ± 0.07 65.41 ± 5.23**
Treated with 100 mg/kg Metformin 135.56 ± 9.72** 68.04 ± 5.80** 127.74 ± 3.16** 126.46 ± 3.68** 76.44 ± 4.72** 129.52 ± 3.96** 0.44 ± 0.07 45.72 ± 4.84**
  1. Results are mean ± SD, n05
  2. GLU glucose, CHOL cholesterol, CRE creatinine, ALP alkaline phosphatase, ALT alanine transaminase, AST aspartate transaminase, GST Glutathione S-transferase, BUN blood urea nitrogen
  3. Values are expressed as mean ± SD for six animals in each group. *Level of significance p < 0.05, **Level of significance p < 0.01