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Table 1 Chemopreventive effect of hydro-methanol Rumex abyssinicus rhizome extract on the post-initiation of aberrant crypt foci (ACF) in six weeks DMH treatment induced colon carcinogenesis

From: Effect of Rumex Abyssinicus on preneoplastic lesions in dimethylhydrazine induced colon carcinogenesis in rats

Animal group N Treatment AC ACF Crypt multiplicity
Mean ± SD Mean ± SD Mean ± SD
Group I 5 Saline 0 0 0
Group II 5 DMH 103.60 ± 21.04 24.80 ± 3.56 4.17 ± 0.64
Group III 5 PI 250 mg/kg + DMH 41.40 ± 9.66ac 11 ± 3.00ac 3.83 ± 0.39NSc
Group IV 5 PI 500 mg/kg + DMH 33.20 ± 6.14bc 8.80 ± 1.64ac 3.78 ± 0.19NSc
  1. AC aberrant crypt, ACF aberrant crypt foci, crypt multiplicity the mean total of AC counted/mean total of ACF, DMH 1,2-dimethylhydrazine, N number of rats, PI post-initiation, SD standard deviation
  2. a, b, NSare all P-values where a< 0.001, b< 0.0001 and NS is not statistically significant
  3. cPost-initiation 250 mg/kg OR post-initiation 500 mg/kg versus DMH