Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS)

Sun, Jianhua; Wu, Xiaoliang; Meng, Yunfang; Cheng, Jie; Ning, Houxu; Peng, Yongjun; Pei, Lixia; Zhang, Wei

doi:10.1186/s12906-015-0863-5

BMC Complementary Medicine and Therapies

Table 1 Analysis of the correlation coefficient between various factors and neuropeptides

From: Electro-acupuncture decreases 5-HT, CGRP and increases NPY in the brain-gut axis in two rat models of Diarrhea-predominant irritable bowel syndrome(D-IBS)

Dependent Variables(Y)	Predictors: (Constant)(X)	R	R Square	Adjusted R Square	Linear Regression(Y = B₀ + B₁X₁ + B₂X₂ + … + B_nX_n)	Model	B	Std. Error	Beta	t	Sig.
body weight	NPY in the colon, hypothalamus, spinal cord	Excluded									>0.05
body weight	5-HT in the colon, hypothalamus, spinal cord	Excluded									>0.05
body weight	CGRP in the colon, hypothalamus, spinal cord	Excluded									>0.05
fecal pellets at 1 h	X is CGRP in spinal cord	0.666	0.444	0.417	Y = −2.916 + 0.140X	(Constant)	−2.916	0.836		−3.489	0.001
	X is CGRP in spinal cord					CGRP of spinal cord	0.14	0.047	0.361	2.96	0.004
	Excluded Variables: CGRP in the colon, hypothalamus					CGRP of colon	0.105	0.06	0.195	1.749	0.085
	Excluded Variables: CGRP in the colon, hypothalamus					CGRP of hypothalamus	0.076	0.04	0.239	1.92	0.059
fecal pellets at 1 h	X₁ is 5-HT of colon, X₂ is 5-HT of spinal cord	0.588	0.345	0.325	Y = −2.005 + 0.013X₁ + 0.012X₂	(Constant)	−2.005	0.806		−2.487	0.016
	X₁ is 5-HT of colon, X₂ is 5-HT of spinal cord					5-HT of colon	0.013	0.004	0.377	3.271	0.002
	Excluded Variables: 5-HT of hypothalamus					5-HT of spinal cord	0.012	0.005	0.304	2.633	0.011
fecal pellets at 1 h	X is NPY of spinal cord	0.568	0.322	0.29	Y = 9.619-0.003X	(Constant)	9.619	1.332		7.221	<0.0001
	X is NPY of spinal cord					NPY of spinal cord	−0.003	0.001	−0.408	−3.762	<0.0001
	Excluded Variables: NPY of colon, hypothalamus					NPY of colon	−0.001	0.001	−0.166	−1.421	0.16
	Excluded Variables: NPY of colon, hypothalamus					NPY of hypothalamus	0	0.001	−0.18	−1.547	0.127
fecal pellets at 1 h	X₁is CGRP of spinal cord, X₂ is NPY of spinal cord	STEP EXCLUDED			Y = 3.367 + 0.202X₁-0.003X₂	(Constant)	3.367	1.289		2.613	0.011
						CGRP of spinal cord	0.202	0.035	0.521	5.809	<0.0001
						NPY of spinal cord	−0.003	0.001	−0.391	−4.363	<0.0001
	Excluded Variables: 5-HT of colon, spinal cord, NPY of spinal cord					5-HT of spinal cord	.258a	2.349	0.022	0.282	0.769
						5-HT of colon	.392a	4.267	0	0.471	0.928
						NPY of spinal cord	-.391a	−4.363	0	−0.479	0.961
sacchar-intake amount	X is CGRP of spinal cord	0.682	0.466	0.44	Y = 39.289-0.635X	(Constant)	39.289	2.195		17.903	<0.0001
	X is CGRP of spinal cord					CGRP of spinal cord	−0.635	0.124	−0.61	−5.105	<0.0001
	Excluded Variables: CGRP of colon, hypothalamus					CGRP of colon	−0.234	0.158	−0.162	−1.478	0.144
	Excluded Variables: CGRP of colon, hypothalamus					CGRP of hypothalamus	0.024	0.104	0.029	0.235	0.815
sacchar-intake amount	X is 5-HT of spinal cord	0.418	0.175	0.162	Y = 33.278-0.045X	(Constant)	33.278	2.229		14.929	<0.0001
sacchar-intake amount	Excluded Variables: 5-HT of colon, hypothalamus	0.418	0.175	0.162	Y = 33.278-0.045X	5-HT of spinal cord	−0.045	0.012	−0.418	−3.711	<0.0001
sacchar-intake amount	X₁ is NPY of colon, X₂ is NPY of hypothalamus	0.541	0.292	0.259	Y = 9.175 + 0.005X₁ + 0.004X₂	(Constant)	9.175	3.648		2.515	0.014
	X₁ is NPY of colon, X₂ is NPY of hypothalamus					NPY of colon	0.005	0.002	0.279	2.336	0.023
	Excluded Variables: NPY of spinal cord					NPY of hypothalamus	0.004	0.002	0.271	2.275	0.026
	Excluded Variables: NPY of spinal cord					NPY of spinal cord	0.004	0.003	0.171	1.544	0.128
sacchar-intake amount	X is CGRP of spinal cord	STEP EXCLUDED			Y = 37.323-0.696X	(Constant)	37.323	1.731		21.567	<0.0001
	X is CGRP of spinal cord					CGRP of spinal cord	−0.696	0.096	−0.668	−7.245	<0.0001
	Excluded Variables: 5-HT of spinal cord, NPY of hypothalamus, colon					5-HT of spinal cord	–.126a	−1.2	0.234	−0.148	0.769
						NPY of hypothalamus	.136a	1.285	0.203	0.159	0.755
						NPY of colon	.173a	1.701	0.094	0.208	0.798
AWR1	X is CGRP of spinal cord	0.556	0.309	0.299	Y = 0.624-0.015X	(Constant)	0.624	0.05		12.403	<0.0001
AWR1	X is CGRP of spinal cord	0.556	0.309	0.299	Y = 0.624-0.015X	CGRP of spinal cord	−0.015	0.003	−0.556	−5.398	<0.0001
AWR2	X is CGRP of spinal cord	0.627	0.394	0.384	Y = 1.069-0.023X	(Constant)	1.069	0.063		16.993	<0.0001
AWR2	X is CGRP of spinal cord	0.627	0.394	0.384	Y = 1.069-0.023X	CGRP of spinal cord	−0.023	0.003	−0.627	−6.494	<0.0001
AWR3	X is CGRP of spinal cord	0.657	0.432	0.423	Y = 1.48-0.03X	(Constant)	1.48	0.076		19.557	<0.0001
AWR3	X is CGRP of spinal cord	0.657	0.432	0.423	Y = 1.48-0.03X	CGRP of spinal cord	−0.03	0.004	−0.657	−7.034	<0.0001
AWR4	X is CGRP of spinal cord	0.633	0.4	0.391	Y = 1.73-0.03X	(Constant)	1.73	0.082		21.21	<0.0001
AWR4	X is CGRP of spinal cord	0.633	0.4	0.391	Y = 1.73-0.03X	CGRP of spinal cord	−0.03	0.005	−0.633	−6.585	<0.0001
AWR3	X is 5-HT of spinal cord	0.333	0.111	0.098	Y = 1.244-0.002X	(Constant)	1.244	0.1		12.461	<0.0001
AWR3	X is 5-HT of spinal cord	0.333	0.111	0.098	Y = 1.244-0.002X	5-HT of spinal cord	−0.002	0.001	−0.333	−2.851	0.006
AWR4	X is 5-HT of spinal cord	0.295	0.087	0.073	Y = 1.47-0.001X	(Constant)	1.47	0.106		13.853	<0.0001
AWR4	X is 5-HT of spinal cord	0.295	0.087	0.073	Y = 1.47-0.001X	5-HT of spinal cord	−0.001	0.001	−0.295	−2.49	0.015

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