Fig. 2

Effect of oral administration of the methanol/methylene chloride extract of the stem bark of Croton macrostachyus (MECM) on the mechanical hyperalgesia assessed with von Frey hair (0.4 g) in mice paw after sciatic nerve partial ligation (PSNL). In panel (a), response to pain was evaluated before the first administration of the day while in panel (b) it was evaluated 2 h after the first administration of the day. N = 5; ^ap < 0.05; ^bp < 0.01; ^cp < 0.001 significantly different compared to vehicle at each time point. B1 = basal response to mechanical stimulation before operation, B2 = basal response to mechanical stimulation 5 days after operation