Table 3 Chromosomal aberration assay and relative cell counts of ORSE
From: Genotoxicity evaluation of Oryeong-san water extract using in vitro and in vivo tests
Nominal conc. of ORSE (μg/mL) | S9 mix | Time hours a) | Mean total aberrant metaphases | Mean total aberrations | Mean of PP + ER | Relative cell counts (%) |
|---|---|---|---|---|---|---|
6 h treatment (+S9) | ||||||
0 | + | 6–18 | 2.0/1.0 | 2.0/1.0 | 1.0 + 0.0 | 100 |
1250 | + | 6–18 | 0.0/0.0 | 0.0/0.0 | 1.0 + 0.5 | 108 |
2500 | + | 6–18 | 0.5/0.5 | 0.5/0.5 | 0.0 + 0.0 | 107 |
5000 | + | 6–18 | 1.5/1.5 | 1.5/1.5 | 0.0+ 0.0 | 103 |
CPA 6 | + | 6–18 | 25.5/25.5** | 36.0/36.0 | 0.5 + 0.0 | 78 |
6 h treatment (-S9) | ||||||
0 | - | 6–18 | 0.0/0.0 | 0.0/0.0 | 0.5 + 0.0 | 100 |
1250 | - | 6–18 | 0.0/0.0 | 0.0/0.0 | 0.0 + 0.0 | 103 |
2500 | - | 6–18 | 1.0/1.0 | 1.0/1.0 | 0.0 + 0.0 | 103 |
5000 | - | 6–18 | 0.5/0.5 | 0.5/0.5 | 1.5 + 0.0 | 93 |
EMS 800 | - | 6–18 | 28.5/28.5** | 36.0/36.0 | 0.0 + 0.0 | 64 |
22 h treatment (-S9) | ||||||
0 | - | 22-2 | 0.0/0.0 | 0.0/0.0 | 1.0 + 0.0 | 100 |
1250 | - | 22-2 | 0.5/0.5 | 1.0/1.0 | 0.0 + 0.0 | 103 |
2500 | - | 22-2 | 0.0/0.0 | 0.0/0.0 | 0.0 + 0.0 | 102 |
5000 | - | 22-2 | 0.0/0.0 | 0.0/0.0 | 0.0 + 0.0 | 70 |
EMS 600 | - | 22-2 | 33.0/33.0** | 46.5/46.5 | 0.5 + 0.0 | 58 |