Fig. 7
From: Pre-administration of turmeric prevents methotrexate-induced liver toxicity and oxidative stress
Schematic representation of the beneficial effects of turmeric on MTX induced liver toxicity. Turmeric plays an important role in modification of liver injury caused by MTX. The turmeric mostly exerts its effects by regulation of antioxidant capacity including enzymatic (SOD and CAT) and non-enzymatic antioxidants (GSH) as well as lipid peroxidation. It also modulates some liver related biochemical parameters causing in improvement of biliary and hepatic synthetic functions. Interestingly turmeric can normalize the histological changes in hepatocytes induced by MTX such as decrease in periportal degeneration, hyperemia, necrosis, and prevention of inflammatory cells infiltration