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Table 3 Chemosuppressive effect of crude aqueous, chloroform and methanol leaf extracts of O. quadripartita in P. berghei-infected mice

From: Effect of crude leaf extract of Osyris quadripartita on Plasmodium berghei in Swiss albino mice

Description Dose (mg/kg/day) % parasitaemia p-value % suppression MST ± SEM p-value
Aqueous 200 63.02 ± 3.91 0.740 0.37 6.2 ± 0.37 0.418
400 54.62 ± 2.20 0.142 16.53 7.4 ± 0.51* 0.018
600 51.26 ± 2.05 0.056 21.67 8.2 ± 0.37* 0.001
Methanol 200 55.92 ± 0.84 0.196 14.5 7.4 ± 0.51* 0.018
400 50.94 ± 1.24 0.510 22.16 8.2 ± 0.37* 0.001
600 49.48 ± 2.06* 0.033 24.4 8.4 ± 0.24* 0.000
Chloroform 200 44.48 ± 10.18* 0.006 31.7 8.0 ± 1.14* 0.004
400 40.7 ± 9.66* 0.001 37.5 9.8 ± 0.58* 0.000
600 38.26 ± 8.78* 0.001 41.26 11 ± 0.63* 0.000
DH2O (NC) 0.2 ml 65.44 ± 1.7 - 0.00 5.6 ± 0.24  
T-80 (NC) 0.2 ml 65.14 ± 1.7 - 0.00 5.8 ± 0.37  
CQ 25 0.00 0.000 100 ND  
  1. Keys: mg/kg/day: 1 mg of extract per one kilogram of mice for one day; MST: mean survival time; SEM: standard error of the mean; NC: negative control; T-80 = Tween-80 (NC for chloroform extract); dH2O: distilled water (NC for aqueous and methanol extract); CQ: chloroquine phosphate; ND: no death *: significant compared with that of NC