Fig. 5

Inhibitory effects of different chemicals on M. canis PQ loop repeat protein (PQ-LRP) gene expression. Different letters in the bars show significantly difference (P <0.05)After 6 h of incubation, the relative mRNA expressions of PQ-LRP in drug-treated groups were significantly higher than those of DMSO and Negative control groups (P < 0.05). After 18 h, the relative mRNA expressions of PQ-LRP in B-P and B groups were significantly higher than those in DMSO and Negative control groups (P < 0.05). The relative mRNA expression of PQ-LRP in the B-P group was also significantly higher than that in the berberine group and the clotrimazole group (P < 0.05). After 30 h, the relative mRNA expression of PQ-LRP in the B-P group was significantly higher than that in the other groups except in the palmatine group (P < 0.05)