Figure 5From: Fructus mume alleviates chronic cerebral hypoperfusion-induced white matter and hippocampal damage via inhibition of inflammation and downregulation of TLR4 and p38 MAPK signalingEffects of F. mume on the activation of TLR4 and p38 MAPK signaling. (A and B) Representative western blots of TLR4, MyD88, phospho-p38 MAPK, p38 MAPK, and GAPDH. Densitometry was performed for TLR4, MyD88, phospho-p38 MAPK, and p38 MAPK normalized to GAPDH using Image J (v1.37) software. (A and B) The hippocampal levels of TLR4, MyD88, and phospho-p38 MAPK were increased in the BCCAo + Vehicle group (n = 10) (*) compared to the sham-operated group (n = 8). Treatment with F. mume (n = 8) decreased the hippocampal levels of TLR4, MyD88, and phospho-p38 MAPK increased by chronic BCCAo (#). Data were analyzed via ANOVA followed by the Tukey test. *, p < 0.05 versus the BCCAo + Vehicle group; #, p <0.05 versus the BCCAo + F. mume group.Back to article page