Mechanisms of gastroprotection of methanol extract of Melastoma malabathricum leaves

Table 4 Effect of methanol extract of M. malabathricum leaves (MEMM), quercitrin and ranitidine on levels of glutathione peroxidase (GTP), glutathione reductsase (GTR) and thiobarbituric acid reactive substances (TBARS) in rats of ethanol-induced gastric tissues

Experimental groups	GTP (nmol min⁻¹ mg of protein⁻¹)	GTR (nmol min⁻¹ mg of protein⁻¹)	TBARS (nmol TBARS⁻¹ mg of protein¹)
Normal (Untreated)	316.22 ± 52.77	28.37 ± 0.91	2.81 ± 0.23
Negative Control (Ethanol)	127.83 ± 20.84*	12.74 ± 0.77*	6.27 ± 0.56*
100 mg/kg Ranitidine + Ethanol	186.81 ± 26.73^#	14.39 ± 1.96	4.13 ± 1.07^#
250 mg/kg MEMM + Ethanol	271.56 ± 41.31^#	15.62 ± 1.01^#	4.29 ± 0.33^#
500 mg/kg MEMM + Ethanol	310.18 ± 30.07^#	18.86 ± 2.34^#	3.01 ± 0.92^#
50 mg/kg Qurcitrin + Ethanol	201.16 ± 13.45^#	17.33 ± 0.84^#	3.17 ± 0.12^#
250 mg/kg Qurcitrin + Ethanol	308.24 ± 22.87^#	25.76 ± 1.41^#	2.25 ± 0.33^#

The results were expressed as mean ± SEM.
*significant at p < 0.05 when compared against the normal (untreated) group using the Student’s t-test.
^#significant at p < 0.05 when compared against the negative control (ethanol-treated) group using the ANOVA followed by Dunnett’s test.

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