Figure 2

Betulin and its derivatives cause morphological changes in HBL100 cells. After treating HBL-100 cells with 10 μg/mL of K02 (B), K03 (C), K04 (D) or K06 (E) for 48 h, cell morphology changed to star-shaped and linear-shaped with vacuolation, and cell density significantly decreased. In the DMSO control group (A, 0.1% DMSO), cell shapes were intact and flat with higher density.