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Table 2 Effect of ZO-ActFr (50 mg/kg) administered 30 minutes before saline administration, on the basal level of neurotransmitters and their metabolites (ng/mg tissue wet weight) in the brain areas and intestine in pigeons at t = 3 hr (n = 6–8)

From: Anti-emetic mechanisms of zingiber officinale against cisplatin induced emesis in the pigeon; behavioral and neurochemical correlates

Treatment NA DOPAC DA 5HIAA HVA 5HT
Area postrema
Saline 0.610 ± 0.014 0.382 ± 0.111 0.590 ± 0.146 0.158 ± 0.036 0.913 ± 0.095 0.062 ± 0.034
MCP 30 mg 0.023 ± 0.005 0.017 ± 0.006 0.025 ± 0.012 0.005 ± 0.001* 0.121 ± 0.063* 0.023 ± 0.001
ZO-ActFr 50 mg 0.372 ± 0.036 0.122 ± 0.047 0.191 ± 0.037 0.039 ± 0.006 0.874 ± 0.204 0.045 ± 0.008
Brain stem
Saline 0.094 ± 0.022 0.060 ± 0.020 0.175 ± 0.078 0.060 ± 0.021 0.060 ± 0.016 0.010 ± 0.003
MCP 30 mg 0.119 ± 0.033 0.027 ± 0.006 0.044 ± 0.012 0.007 ± 0.001*** 0.066 ± 0.031 0.019 ± 0.002
ZO-ActFr 50 mg 0.056 ± 0.055 0.128 ± 0.127 0.082 ± 0.054 0.011 ± 0.001* 0.088 ± 0.021 0.020 ± 0.001
Intestine
Saline 0.194 ± 0.059 0.067 ± 0.020 0.090 ± 0.064 0.076 ± 0.058 0.056 ± 0.025 0.049 ± 0.016
MCP 30 mg 0.138 ± 0.039 0.054 ± 0.025 0.059 ± 0.018 0.097 ± 0.022 0.198 ± 0.102 0.062 ± 0.013
ZO-ActFr 50 mg 0.334 ± 0.131 0.037 ± 0.028 0.356 ± 0.113 0.050 ± 0.008 0.231 ± 0.110 0.103 ± 0.015
  1. Standard MCP is also shown.
  2. Values significantly different compared to basal level (saline) are indicated as *p < 0.05, ***p < 0.001 (ANOVA followed by Tukey post hoc analysis).