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Table 3 Organ weights index of the mice xenografted with S180 cells and LLC cells

From: Evaluation of antitumor property of extracts and steroidal alkaloids from the cultivated Bulbus Fritillariae ussuriensis and preliminary investigation of its mechanism of action

Groups Dose (mg/kg) Growth of weight (g) Organ indices (mg/g)
Spleen Thymus Heart Liver Lung Kidney
S180 tumor model
Control - 4.08 ± 0.61 7.02 ± 0.70 2.24 ± 0.22 5.17 ± 0.40 63.71 ± 3.53 6.88 ± 0.52 13.01 ± 0.61
TAFU 20 2.36 ± 0.81### 6.86 ± 0.20## 2.43 ± 0.35## 4.34 ± 0.12 63.28 ± 2.10# 7.29 ± 0.37 13.00 ± 0.50
  40 2.84 ± 0.74# 6.67 ± 0.17## 1.98 ± 0.12*, # 4.67 ± 0.20 56.04 ± 1.11* 6.62 ± 0.21 12.29 ± 0.37
  80 2.45 ± 0.50## 5.43 ± 0.11*, # 1.84 ± 0.17* 4.55 ± 0.30 58.50 ± 0.82 6.39 ± 0.45 12.88 ± 0.63
CTX 20 −1.82 ± 0.64*** 4.26 ± 0.16*** 1.30 ± 0.15** 4.73 ± 0.18 52.72 ± 3.30* 6.75 ± 0.39 12.81 ± 0.59
LLC tumor model
Control - 0.64 ± 0.48 6.07 ± 0.91 1.57 ± 0.32 5.93 ± 0.48 57.54 ± 3.99 6.90 ± 0.52 13.63 ± 0.60
TAFU 20 0.58 ± 0.68### 7.74 ± 0.57## 1.25 ± 0.13### 5.22 ± 0.32# 58.69 ± 1.32# 7.20 ± 0.33* 12.54 ± 0.55
  40 0.37 ± 0.32*, ## 7.53 ± 0.38## 1.18 ± 0.04## 5.25 ± 0.43# 53.44 ± 1.20# 7.33 ± 0.10 11.17 ± 0.22
  80 0.29 ± 0.50*, ## 5.68 ± 0.82# 1.09 ± 0.07*, ## 4.86 ± 0.12* 53.85 ± 4.96# 6.87 ± 0.60# 11.69 ± 0.40
CTX 20 −1.88 ± 0.71*** 4.05 ± 0.42** 0.41 ± 0.05*** 4.38 ± 0.17* 44.34 ± 3.59* 6.80 ± 0.54 11.96 ± 0.62
  1. The reported values are the means ± S.E.M. (n = 10). Significant differences compared with Control group were designated as *P < 0.05, **P < 0.01 and ***P < 0.001; and those compared with CTX group as #P < 0.05, ##P < 0.01 and ###P < 0.001.