Figure 5

PPC affects the Th1/Th2 cytokine expression pattern. Balb/c mice (4/group) were injected i.p. on day 0 and day 14 with 10 μg OVA formulated in alum and then on day 28 the serum IgE levels were measured. Mice in the OVA + PPC group received 200 μg/mL of PPC in their drinking water beginning 7 days before (day -7) the first OVA injection and continued throughout the entire 28 day period. The serum IgE levels are shown for untreated (Naïve), OVA vaccinated (OVA) and PPC treated mice that had been vaccinated with OVA (OVA + PPC). The differences between the IgE and IL-4, and IFNγ levels in the OVA and OVA + PPC groups are significant (p < 0.001 and 0.01, 0.01, respectively). Error bars represent the standard deviation. The (**) represents a p < 0.01 while the (***) represents a p < 0.001.