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Table 3 Proteins up regulated by F4 Fraction

From: Petiveria alliacea extracts uses multiple mechanisms to inhibit growth of human and mouse tumoral cells

Up regulated Proteins Accesion Number
Translational Proteins  
Alanyl t-RNA synthetase variant BAD96544
CDA02 (Eukaryotic translation initiation factor 2A) AAK14926
Eukaryotic translation initiation factor 2, subunit 1 alpha, 35 kDa NP_001406
Eukaryotic translation initiation factor 3 subunit A, KIAA0139 BAA09488
GA17 protein (eukaryotic translation initiation factor 3, subunit M) NP_006351
GCN1 general control of amino-acid synthesis 1-like 1, KIAA0219 BAA13209
Leucyl-tRNA synthetase, cytoplasmic, KIAA1352 BAA92590
Methionine adenosyltransferase II, alpha NP_005902
Mitochondrial isoleucine tRNA synthetase NP_060530
Prt1 homolog, Eukaryotic translation initiation factor 3 subunit B AAB42010
Synaptotagmin binding RNA interacting protein, SYNCRIP AAH24283
Transcription processing  
DNA-binding protein A (Cold shock domain-containing protein A) P16989
Heterogeneous nuclear ribonucleoprotein M isoform a NP_005959
Small nuclear ribonucleoprotein polypeptide F NP_003086
Small nuclear ribonucleoprotein Sm D1 CAE11897
Ribosomal Proteins  
Ribosomal protein S15 NP_001004
Ribosomal protein S9 NP_001009
Ribosomal Protein S3A NP_000996
Protein Degradation  
Proteasa de Cisteina del Retículo (ER60) BAA11928
Proteasome 26S ATPase subunit 1 variant BAD96388
Proteasome 26S ATPase subunit 2 NP_002794
Proteasome 26S non-ATPase subunit 11 variant BAD96916
Proteasome 26S non-ATPase subunit 2 variant BAD93080
Putative ubiquitin-conjugating enzyme E2 D3-like protein Q9NTT1
SUMO1 activating enzyme subunit 1 NP_005491
Tripeptidyl peptidase II CAH72178
Ubiquitin-Activating enzime E1 NP_003325
Transporters  
Amino acid transporter E16 AAC61479
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 isoform 1 NP_733765
Coatomer protein complex subunit alpha isoform 1 (Cop I) NP_001091868
Exportin 1 NP_003391
Karyopherin beta 1, Importin subunit beta-1 NP_002256
SEC13-like 1 (S. cerevisiae), isoform CRA_b EAW64078
Signal recognition particle 72 kDa NP_008878
Solute carrier family 25 (mitochondrial carrier, Aralar), member 12 NP_003696
Stomatin AAH10703
Cytoskeleton  
Actin related protein 2/3 complex subunit 2 NP_005722
ARP3 actin-related protein 3 homolog NP_005712
Chaperonin containing TCP1-subunit 2 beta EAW97230
Chaperonin containing TCP1-subunit 3 gamma BAD92119
Destrin, isoform a NP_006861
Dynactin 1 isoform 1 NP_004073
Dynamin 1-like, isoform CRA_c EAW88521
Filamin A, FLJ00343 AAF72339
MYO1C variant protein (myosin-I beta) BAE06097
T-complex protein 1 subunit epsilon, KIAA0098 BAA07894
Transgelin-2, KIAA0120 BAA04802
Cell Cycle  
Alpha isoform of regulatory subunit A, protein phosphatase 2 NP_055040
Minichromosome maintenance complex component 6 NP_005906
Poly (ADP-ribose) polymerase family, member 1 NP_001609
Regulator of chromosome condensation 1, isoform CRA_c EAX07692
Septin 9, KIAA0991 BAA76835
Signal Transduction  
GTP-binding protein PTD004 isoform 1 NP_037473
Phosphofructokinase, platelet, isoform CRA_a EAW86495
Protein kinase C inhibitor protein 1, YWHAZ AAH51814
Chaperones  
Calnexin precursor NP_001737
Nucleophosmin AAW67757
Oxygen regulated protein precursor NP_006380
TNF receptor-associated protein 1 variant BAD93042
Metabolism  
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase NP_004035
Acyl-CoA synthetase long-chain family 3 NP_976251
Aldehyde dehydrogenase 18 family, member A1 CAI16766
Alkylglycerone phosphate synthase, isoform CRA_b EAX11058
Carbamoylphosphate synthetase 2/aspartate transcarbamylase/dihydroorotase NP_004332
Dolichyl-diphosphooligosaccharide-protein glycosyltransferase CAH73476
Enoyl Coenzyme A hydratase AAH08906
Glucosamine–fructose-6-phosphate aminotransferase (GFAT 1) Q06210
HMT1 hnRNP methyltransferase-like 2 isoform 1 NP_001527
Human rab GDI BAA03095
Hydroxyacyl-Coenzyme A dehydrogenase AAH14572
Inosine monophosphate dehydrogenase 2, hCG2002013 EAW64946
Ornithine aminotransferase precursor NP_000265
Phosphogluconate dehydrogenase NP_002622
Phosphoribosyl pyrophosphate synthetase 2, PRPS2 NP_002756
RPN2 CAG33180
S-adenosylhomocysteine hydrolase NP_000678
  1. Proteins from A375 human cells treated with F4 or ethanol (0.2%) as negative control were digested, and the extracted peptides injected onto a 1100 Series HPLC-Chip Cube MS interface, and Agilent 6300 Series Ion Trap Chip-LC-MS/MS system (Agilent Technologies). Data are the proteins up regulated by F4 fraction treatment as judged by mass spectrometry.