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Table 2 Effect of Momordica charantia extract on liver glycogen levels, glucose uptake by hemidiaphragm and glycogenolysis by liver of alloxan diabetic rats

From: An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract

Oral treatment (n = 8) Liver glycogen g/100 g Glucose uptake by hemidiaphragm mg/100 mg Glucose transfer by liver mg/g Pancreas histoarchetechture necrotic changes & persistence of islets of Langerhans*
  Mean ± SEM
Normal control 3.8 ± 0.4 16.0 ± 0.4 26.9 ± 0.4 0.3 ± 0.01
Diabetic control 1.0 ± 0.2# 4.7 ± 0.2# 42.6 ± 2.2# 3.6 ± 0.13
MCE (150 mg/kg) 1.6 ± 0.2b 8.1 ± 0.3a 17.9 ± 0.4a 2.9 ± 0.2
MCE (300 mg/kg) 1.7 ± 0.1a 15.9 ± 0.4a 15.6 ± 0.7a 1.9 ± 0.12
Glibenclamide 4 mg/kg 1.8 ± 0.1a 14.0± 0.3a 17.9 ± 0.8a 1.8 ± 0.18
  1. Significant difference of diabetic control from normal control: #P < 0.001
  2. Significant difference of treated groups from diabetic control: aP < 0.001, bP < 0.005,
  3. *Scoring system: 0 – Normal, 1 – very mild, 2 – mild, 3 – moderate, 4 – marked