Figure 5From: Abundant expression and functional participation of TRPV1 at Zusanli acupoint (ST36) in mice: mechanosensitive TRPV1 as an “acupuncture-responding channel” TRPV1 agonist (capsaicin) injection at ST36 replicated the analgesic effect of acupuncture. The behavioral test design was similar to that of MA, with the exception that capsaicin was injected at a concentration of 0.5% and a volume of 10 μL into ST36 or sham point. (A) In within-group tests, capsaicin injections into ST36 showed significant effect on D3 post (P < 0.01) and on D4 (P < 0.05). (B) In between-group tests, capsaicin injections at ST36 yielded significant differences compared with injections at the sham point (P < 0.01) and vehicle injections at ST36 (P < 0.05) on D3 post. (C) There were no significant differences in between-group tests on D4. Within-group and between-group tests were designed similar to the MA behavioral test (*P < 0.05, **P < 0.01; Mann–Whitney rank sum test, n = 11–13). Data are means ± S.E.M.Back to article page