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Table 2 Antinociceptive effect of C. rotundus extract and morphine in tail immersion test

From: Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Treatment Dose (mg/kg) Response time (s) (%MPE)
Pretreatment 30 min 60 min 90 min 120 min
Vehicle 0.1 ml/mice 2.83 ± 0.48 2.62 ± 0.37 2.68 ± 0.46 2.66 ± 0.43 2.59 ± 0.48
Morphine sulphate 5 2.66 ± 0.56 5.42 ± 0.47**(37.62) 6.21 ± 0.41**(48.32) 4.64 ± 0.31*(26.00) 3.57 ± 0.40(12.45)
HMCR 50 2.31 ± 0.37 3.25 ± 0.47(12.22) 3.98 ± 0.17(21.71) 3.14 ± 0.12(10.87) 2.62 ± 0.24(4.03)
HMCR 100 2.66 ± 0.12 3.66 ± 0.35(13.61) 4.52 ± 0.32*(25.33) 3.88 ± 0.34*(16.61) 2.97 ± 0.17(4.30)
HMCR 200 2.54 ± 0.49 3.87 ± 0.35(17.88) 4.44 ± 0.36*(25.47) 4.16 ± 0.34*(21.66) 3.14 ± 0.24(8.04)
  1. Each value is presented as the mean ± SEM (n = 5); *p < 0.05 compared with the control group (Dunnett’s test), **p < 0.001 compared with the control group (Dunnett’s test).