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Table 1 Antinociceptive effect of C. rotundus extract and morphine in hot plate test

From: Evaluation of antinociceptive activity of hydromethanol extract of Cyperus rotundus in mice

Treatment Dose (mg/kg) Response time (s) (%MPE)
Pretreatment 30 min 60 min 90 min 120 min
Vehicle 0.1 ml/mice 7.44 ± 0.48 7.89 ± 0.62 7.52 ± 0.86 7.91 ± 0.90 8.44 ± 0.83
Morphine sulphate 5 8.70 ± 0.72 14.89 ± 1.01**(54.72) 18.17 ± 0.66**(83.76) 14.70 ± 0.26**(53.04) 12.99 ± 0.93(37.94)
HMCR 50 8.22 ± 0.91 10.27 ± 0.55(17.45) 11.97 ± 0.28*(31.89) 10.85 ± 0.90(22.35) 9.22 ± 1.32(8.52)
HMCR 100 6.19 ± 0.91 10.11 ± 0.72(28.38) 13.03 ± 1.18**(49.55) 11.63 ± 0.97*(39.43) 10.77 ± 0.83(33.17)
HMCR 200 8.22 ± 0.72 12.21 ± 0.62*(33.89) 13.93 ± 0.63**(48.51) 11.99 ± 0.76*(32.04) 11.07 ± 1.47(24.19)
  1. Each value is presented as the mean ± SEM (n = 5); *p < 0.05 compared with the control group (Dunnett’s test). **p < 0.001 compared with the control group (Dunnett’s test).