| Control | Zyflamend | Rosemary | Turmeric | Barberry | Hu Zhang | Gold Thread | Skull Cap | Holy Basil | Green Tea | Ginger |
---|---|---|---|---|---|---|---|---|---|---|---|
 | Relative mRNA (n = 3)1 | ||||||||||
HDAC1 | 1.00 ± 0.04 | 0.42 ± 0.05* | 0.76 ± 0.07 | 1.28 ± 0.07* | 0.94 ± 0.04 | 0.92 ± 0.02 | 0.57 ± 0.05* | 0.76 ± 0.01* | 1.61 ± 0.02* | 1.22 ± 0.13 | 0.95 ± 0.03 |
HDAC2 | 1.00 ± 0.01 | 0.34 ± 0.03* | 0.79 ± 0.10 | 0.94 ± 0.15 | 0.67 ± 0.07* | 0.70 ± 0.05 | 0.35 ± 0.04* | 0.23 ± 0.02* | 1.09 ± 0.04 | 0.87 ± 0.02* | 0.52 ± 0.06* |
HDAC3 | 1.00 ± 0.02 | 0.17 ± 0.02* | 0.94 ± 0.05 | 0.99 ± 0.06 | 0.58 ± 0.17 | 1.09 ± 0.02 | 0.26 ± 0.01* | 0.35 ± 0.03* | 0.82 ± 0.09 | 0.69 ± 0.05* | 0.91 ± 0.07 |
HDAC4 | 1.00 ± 0.10 | 0.13 ± 0.01* | 1.80 ± 0.09* | 1.84 ± 0.08* | 1.56 ± 0.25 | 1.07 ± 0.05 | 0.59 ± 0.04* | 0.47 ± 0.02* | 1.52 ± 0.12* | 1.35 ± 0.10 | 2.63 ± 0.11* |
HDAC5 | 1.00 ± 0.06 | 0.63 ± 0.06* | 1.21 ± 0.24 | 1.40 ± 0.25 | 1.34 ± 0.05* | 1.18 ± 0.09 | 0.27 ± 0.35* | 0.61 ± 0.02* | 1.12 ± 0.13 | 1.16 ± 0.12 | 1.54 ± 0.14* |
HDAC6 | 1.00 ± 0.03 | 0.20 ± 0.01* | 0.70 ± 0.05* | 0.81 ± 0.12 | 1.16 ± 0.10 | 1.02 ± 0.05 | 0.27 ± 0.01* | 0.38 ± 0.02* | 0.84 ± 0.03* | 0.72 ± 0.13 | 1.22 ± 0.09 |
HDAC7 | 1.00 ± 0.16 | 0.39 ± 0.04* | 1.18 ± 0.02 | 1.64 ± 0.04* | 1.41 ± 0.01 | 1.10 ± 0.04 | 0.53 ± 0.09* | 0.61 ± 0.03* | 1.37 ± 0.09 | 1.47 ± 0.02* | 1.78 ± 0.06* |
 | Relative HDAC activity (n = 3), cellular location: | Cytosolic | Nuclear |  |  |  | |||||
 |  |  |  |  | Control | Zyflamend | Control | Zyflamend |  |  |  |
 |  |  |  |  | 1.00 ± 0.05 | 0.72 ± 0.08* | 1.00 ± 0.08 | 0.75 ± 0.02* |  |  |  |