Chemical composition, antinociceptive, anti-inflammatory and redox properties in vitro of the essential oil from Remirea maritima Aubl. (Cyperaceae)

Table 2 Effect of RMO on writhing induced by acetic acid and formalin-induced nociception tests

Treatment	Dose (mg/kg)	Writhing test	Formalin test
Treatment	Dose (mg/kg)	Number of writhings^a	0-5 min^a	15-30 min^a
Vehicle	-	32.8 ± 2.8	56.3 ± 5.2	115.0 ± 8.7
RMO	50	20.6 ± 2.3^b	43.0 ± 2.92	54.5 ± 4.5^d
RMO	100	18.1 ± 3.6^c	39.0 ± 3.0	54.8 ± 4.3^d
RMO	200	10.1 ± 2.5^d	31.3 ± 5.69^c	38.6 ± 3.6^d
Aspirin	200	3.5 ± 1.7^d	40.1 ± 4.9	35.4 ± 8.9^d

n = 8, per group.
^aValues represent mean ± S.E.M.
^bp < 0.05, ^cp < 0.01 and ^dp < 0.001 (one-way ANOVA and Tukey’s test), significantly different from control group.

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