Growth inhibition of Candida species by Wickerhamomyces anomalus mycocin and a lactone compound of Aureobasidium pullulans

Table 1 In vitro susceptibilities of Candida isolates to a standard preparation of HDCL

Candida spp.	Planktonic MIC (μg/ml)			Biofilm MIC (μg/ml)
Candida spp.	MIC range	MIC₅₀	MIC₉₀	MIC range	MIC₅₀	MIC₉₀
Candida albicans ( n = 15)	128 - 256	256	256	128 - 512	256	256
Nonalbicans Candida species (n = 77)	64 - 256	256	256	64 - 1024	256	256
Candida glabrata (n = 26)	64 - 256	256	256	64 - 512^a	256^a	512^a
C. krusei (n = 17)	128 - 256	128	256	64 - 256	128	256
C. parapsilosis (n = 8)	64 - 256	64	256	128 - 1024^b	128^b	1024^b
C. tropicalis (n = 10)	64 - 256	128	256	256 - 1024	256	512
C. orthopsilosis (n = 8)	128 - 256	256	256	128 - 256^c	128^c	256^c
C. rugosa species complex (n = 5)	128 - 256	128	256	128 - 512	512	512
C. dubliniensis (n =1)	128	ND	ND	256	ND	ND
M. guelliermondii (n =1)	128	ND	ND	128	ND	ND
C. metapsilosis (n =1)	256	ND	ND	128	ND	ND
All isolates (n = 92)	64 - 256	256	256	64 - 1024	256	512

Footnote: Planktonic MIC: The lowest concentration of HDCL required to inhibit yeast growth after incubation at 37°C for 48 h.
Biofilm MIC: The lowest concentration of HDCL required to cause 50% reduction in biofilm metabolic activity after incubation at 37°C for 48 h.
MIC₅₀ and MIC₉₀ values were only calculated for those species with 5 or more isolates.
ND: Not determined.
^{a, b, c}: Five Candida glabrata and two each of C. parapsilosis and C. orthopsilosis isolates were excluded from the study due to poor biofilm formation (OD_490nm < 0.1).

ISSN: 2662-7671