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Table 1 Cytotoxicity results of A.carnosus extracts by MTT assay

From: Cytotoxic potential of Anisochilus carnosus (L.f.) wall and estimation of luteolin content by HPLC

Concentration (μg/ml) % Viability
Aqueous extract Ethanolic extract Pet. ether extract Paclitaxel
0 100 ± 5.875 100 ± 5.875 100 ± 5.875 100 ± 2.09
6.25 - - - 80.32 ± 0.366**
12.5 - - - 42.56 ± 1.863**
25 94.04 ± 1.729 75.26 ± 2.654* 44.92 ± 2.631** 22.83 ± 1.22**
50 80.87 ± 2.462* 54.14 ± 4.610** 30.23 ± 3.662** 10.66 ± 0.46**
100 71.12 ± 1.950** 26.66 ± 2.951** 12.73 ± 4.242** -
200 58.79 ± 2.278** 12.06 ± 1.104** 8.16 ± 1.063** -
IC 50 value 238.91 58.64a 18.35a, b 11.34b
  1. Results were expressed as Mean ± SEM (n = 3) and analysed using one-way ANOVA followed by Tukey’s post hoc test of significance [where different alphabets denote significant difference (p <0.05)]. Statistical comparison between the mean % viability of each extract and its negative control was performed using one-way ANOVA followed by Dunnett’s post hoc test of significance wherein *p <0.05 and **p <0.01 were considered to be statistically significant and very statistically significant compared to negative control. A.carnosus extracts were tested at concentrations of 200, 100, 50, 25 μg/ml (they were not tested at concentrations of 6.25 and 12.5 μg/ml). Paclitaxel was tested at concentrations of 6.25, 12.5, 25 and 50 μg/ml.