Figure 2

FGS post-treatment does not reduce lung inflammation in Nrf2 KO mice. (A) WT and Nrf2 KO mice (n = 5 per group) received an i.p. PBS or LPS (10 mg/kg body weight). At 2 h after injection, half of each mice group received either an i.t PBS or FGS (150 μg/kg body weight). At 24 h after LPS treatment, lung sections of the mice were stained with H&E for histological examination (magnification × 100). Shown are representatives of at least five different areas of a lung. BAL was performed to differentially count total cells (B) and neutrophils (C) infiltrated to the lungs of WT and Nrf2 KO mice. Data represent the mean ± SEM of 5 mice. * P was less than 0.05, compared with LPS only. Nrf2 KO mice show no significant difference between two different treatments.