Figure 5From: Antidepressant-like effects of the hydroalcoholic extracts of Hemerocallis Citrina and its potential active components Effects of HCE75, the standardized flavonoid mixture containing equivalent rutin, hesperidin, quercetin, and quercitrin doses and the fixed-ratio combination of rutin and hesperidin (75:21.5, w/w), on (A) immobility time in TST and (B to D) their respective line crossings in OFT. The mice were tested 1 h after administration (p.o.) of the vehicle (physiological saline with 10% Tween 80), fluoxetine (20 mg/kg), HCE75 (20, 200, 400, 800, and 1600 mg/kg), standardized flavonoid mixtures (0.4, 4, 8, 16, and 32 mg/kg), and the fixed-ratio rutin and hesperidin combination (0.4, 4, 8, 16, and 32 mg/kg). Data are expressed as mean ± S.E.M. (n = 10). Data were analyzed using one-way ANOVA for multiple comparisons, followed by post hoc Student–Newman–Keuls test. *p < 0.05, **p < 0.01, and ***p < 0.001 compared with the control group (vehicle); ##p < 0.01 and ###p < 0.001 compared with the positive reference group (fluoxetine).Back to article page