Effect of Nigella sativa fixed and essential oils on antioxidant status, hepatic enzymes, and immunity in streptozotocin induced diabetes mellitus

Table 4 Effects of N. sativa fixed and essential oil on indices of immune system in diabetic rats

Parameters	Diets	Study intervals (Days)
Parameters	Diets	0	28	56
Xanthine oxidase (IU/mg protein)	D ₁	26.13 ± 1.51c	29.82 ± 0.97b	32.13 ± 1.63a
	D ₂	29.03 ± 1.21b	28.28 ± 0.95bc	25.10 ± 1.11d
	D ₃	29.45 ± 1.12b	26.33 ± 1.28 cd	19.33 ± 0.86e
Myeloperoxidase (IU/mg protein)	D ₁	15.66 ± 0.904c	17.34 ± 0.562b	20.65 ± 1.047a
	D ₂	16.09 ± 0.673c	13.53 ± 0.455d	13.28 ± 0.585d
	D ₃	16.08 ± 0.612c	12.42 ± 0.605e	10.85 ± 0.482f
Nitric oxide (nmol/dL )	D ₁	23.42 ± 1.35d	25.98 ± 0.84b	27.13 ± 1.38a
	D ₂	23.47 ± 0.98c	21.58 ± 0.73d	21.22 ± 0.93d
	D ₃	24.79 ± 0.94bc	21.21 ± 1.03d	17.43 ± 0.77e

Means sharing same letters in a column/row do not differ significantly at P < 0.05.
D₁ = control diet; D₂ = N. sativa seed fixed oil; D₃ = N. sativa seed essential oil.