Table 2 Gene ontology groups with significant over-representation among genes with significantly changed expression in the BerH (FDR < 0.001)
From: Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine
GO classification | Go term | GO ID | Count | Fold enrichment | FDR |
|---|---|---|---|---|---|
Biological process | Intracellular signaling cascade | GO:0007242 | 60 | 7.195 | 1.61E-18 |
Phosphate metabolic process | GO:0006796 | 55 | 7.186 | 1.06E-17 | |
Phosphorus metabolic process | GO:0006793 | 55 | 7.169 | 1.20E-17 | |
Protein kinase cascade | GO:0007243 | 34 | 14.126 | 7.10E-16 | |
Regulation of phosphorylation | GO:0042325 | 37 | 10.287 | 1.03E-15 | |
Regulation of phosphate metabolic process | GO:0019220 | 37 | 9.890 | 4.11E-15 | |
Regulation of phosphorus metabolic process | GO:0051174 | 37 | 9.890 | 4.11E-15 | |
Protein amino acid phosphorylation | GO:0006468 | 42 | 7.539 | 2.09E-14 | |
Regulation of kinase activity | GO:0043549 | 32 | 12.455 | 2.41E-14 | |
Regulation of transferase activity | GO:0051338 | 32 | 11.872 | 1.06E-13 | |
Response to organic substance | GO:0010033 | 48 | 5.738 | 2.16E-13 | |
Regulation of protein kinase activity | GO:0045859 | 30 | 12.280 | 1.81E-12 | |
Phosphorylation | GO:0016310 | 42 | 6.516 | 5.62E-12 | |
MAPKKK cascade | GO:0000165 | 24 | 18.618 | 9.75E-12 | |
Positive regulation of kinase activity | GO:0033674 | 26 | 14.494 | 5.94E-11 | |
Positive regulation of transferase activity | GO:0051347 | 26 | 13.866 | 1.81E-10 | |
Response to endogenous stimulus | GO:0009719 | 37 | 7.163 | 2.64E-10 | |
Positive regulation of molecular function | GO:0044093 | 34 | 7.439 | 6.39E-09 | |
Positive regulation of protein kinase activity | GO:0045860 | 24 | 13.939 | 8.79E-09 | |
Positive regulation of catalytic activity | GO:0043085 | 32 | 7.995 | 1.47E-08 | |
Response to hormone stimulus | GO:0009725 | 33 | 7.178 | 8.01E-08 | |
Regulation of apoptosis | GO:0042981 | 32 | 5.243 | 2.47E-06 | |
Regulation of programmed cell death | GO:0043067 | 32 | 5.174 | 3.54E-06 | |
Regulation of cell death | GO:0010941 | 32 | 5.152 | 4.01E-06 | |
Activation of protein kinase A activity | GO:0034199 | 9 | 66.561 | 3.21E-05 | |
Enzyme linked receptor protein signaling pathway | GO:0007167 | 21 | 8.320 | 7.94E-05 | |
Regulation of MAP kinase activity | GO:0043405 | 15 | 14.469 | 2.47E-04 | |
Cellular response to hormone stimulus | GO:0032870 | 16 | 12.588 | 2.76E-04 | |
Negative regulation of catalytic activity | GO:0043086 | 19 | 9.007 | 3.78E-04 | |
cAMP biosynthetic process | GO:0006171 | 8 | 73.957 | 4.80E-04 | |
Activation of protein kinase activity | GO:0032147 | 14 | 15.687 | 6.06E-04 | |
Cellular constituent | Cytosol | GO:0005829 | 46 | 4.618 | 4.08E-17 |
Cell fraction | GO:0000267 | 32 | 3.714 | 9.48E-08 | |
Nucleoplasm | GO:0005654 | 25 | 4.037 | 5.43E-06 | |
Insoluble fraction | GO:0005626 | 25 | 3.716 | 2.73E-05 | |
Soluble fraction | GO:0005625 | 16 | 6.026 | 5.40E-05 | |
Organelle lumen | GO:0043233 | 31 | 2.849 | 1.12E-04 | |
Plasma membrane | GO:0005886 | 45 | 2.108 | 1.93E-04 | |
Membrane-enclosed lumen | GO:0031974 | 31 | 2.772 | 2.06E-04 | |
Nuclear lumen | GO:0031981 | 26 | 3.148 | 3.24E-04 | |
Intracellular organelle lumen | GO:0070013 | 28 | 2.668 | 0.002417965 | |
Molecular function | Protein kinase activity | GO:0004672 | 38 | 7.617 | 4.54E-12 |
Purine ribonucleotide binding | GO:0032555 | 53 | 3.841 | 1.29E-11 | |
Ribonucleotide binding | GO:0032553 | 53 | 3.839 | 1.33E-11 | |
Protein serine/threonine kinase activity | GO:0004674 | 30 | 8.615 | 2.66E-11 | |
Purine nucleotide binding | GO:0017076 | 53 | 3.660 | 1.11E-10 | |
ATP binding | GO:0005524 | 46 | 4.169 | 6.83E-10 | |
Adenyl ribonucleotide binding | GO:0032559 | 46 | 4.087 | 1.47E-09 | |
Adenyl nucleotide binding | GO:0030554 | 46 | 3.856 | 1.44E-08 | |
Purine nucleoside binding | GO:0001883 | 46 | 3.789 | 2.78E-08 | |
Nucleoside binding | GO:0001882 | 46 | 3.759 | 5.66E-08 | |
Nucleotide binding | GO:0000166 | 53 | 3.059 | 3.25E-07 | |
MAP kinase activity | GO:0004707 | 9 | 59.748 | 7.78E-06 | |
Adenylate cyclase activity | GO:0004016 | 8 | 82.079 | 1.34E-05 | |
Phosphoprotein phosphatase activity | GO:0004721 | 15 | 13.329 | 5.76E-05 | |
Kinase binding | GO:0019900 | 16 | 10.031 | 5.56E-04 |