Skip to main content

Advertisement

Table 2 Gene ontology groups with significant over-representation among genes with significantly changed expression in the BerH (FDR < 0.001)

From: Berberine moderates glucose metabolism through the GnRH-GLP-1 and MAPK pathways in the intestine

GO classification Go term GO ID Count Fold enrichment FDR
Biological process Intracellular signaling cascade GO:0007242 60 7.195 1.61E-18
Phosphate metabolic process GO:0006796 55 7.186 1.06E-17
Phosphorus metabolic process GO:0006793 55 7.169 1.20E-17
Protein kinase cascade GO:0007243 34 14.126 7.10E-16
Regulation of phosphorylation GO:0042325 37 10.287 1.03E-15
Regulation of phosphate metabolic process GO:0019220 37 9.890 4.11E-15
Regulation of phosphorus metabolic process GO:0051174 37 9.890 4.11E-15
Protein amino acid phosphorylation GO:0006468 42 7.539 2.09E-14
Regulation of kinase activity GO:0043549 32 12.455 2.41E-14
Regulation of transferase activity GO:0051338 32 11.872 1.06E-13
Response to organic substance GO:0010033 48 5.738 2.16E-13
Regulation of protein kinase activity GO:0045859 30 12.280 1.81E-12
Phosphorylation GO:0016310 42 6.516 5.62E-12
MAPKKK cascade GO:0000165 24 18.618 9.75E-12
Positive regulation of kinase activity GO:0033674 26 14.494 5.94E-11
Positive regulation of transferase activity GO:0051347 26 13.866 1.81E-10
Response to endogenous stimulus GO:0009719 37 7.163 2.64E-10
Positive regulation of molecular function GO:0044093 34 7.439 6.39E-09
Positive regulation of protein kinase activity GO:0045860 24 13.939 8.79E-09
Positive regulation of catalytic activity GO:0043085 32 7.995 1.47E-08
Response to hormone stimulus GO:0009725 33 7.178 8.01E-08
Regulation of apoptosis GO:0042981 32 5.243 2.47E-06
Regulation of programmed cell death GO:0043067 32 5.174 3.54E-06
Regulation of cell death GO:0010941 32 5.152 4.01E-06
Activation of protein kinase A activity GO:0034199 9 66.561 3.21E-05
Enzyme linked receptor protein signaling pathway GO:0007167 21 8.320 7.94E-05
Regulation of MAP kinase activity GO:0043405 15 14.469 2.47E-04
Cellular response to hormone stimulus GO:0032870 16 12.588 2.76E-04
Negative regulation of catalytic activity GO:0043086 19 9.007 3.78E-04
cAMP biosynthetic process GO:0006171 8 73.957 4.80E-04
Activation of protein kinase activity GO:0032147 14 15.687 6.06E-04
Cellular constituent Cytosol GO:0005829 46 4.618 4.08E-17
Cell fraction GO:0000267 32 3.714 9.48E-08
Nucleoplasm GO:0005654 25 4.037 5.43E-06
Insoluble fraction GO:0005626 25 3.716 2.73E-05
Soluble fraction GO:0005625 16 6.026 5.40E-05
Organelle lumen GO:0043233 31 2.849 1.12E-04
Plasma membrane GO:0005886 45 2.108 1.93E-04
Membrane-enclosed lumen GO:0031974 31 2.772 2.06E-04
Nuclear lumen GO:0031981 26 3.148 3.24E-04
Intracellular organelle lumen GO:0070013 28 2.668 0.002417965
Molecular function Protein kinase activity GO:0004672 38 7.617 4.54E-12
Purine ribonucleotide binding GO:0032555 53 3.841 1.29E-11
Ribonucleotide binding GO:0032553 53 3.839 1.33E-11
Protein serine/threonine kinase activity GO:0004674 30 8.615 2.66E-11
Purine nucleotide binding GO:0017076 53 3.660 1.11E-10
ATP binding GO:0005524 46 4.169 6.83E-10
Adenyl ribonucleotide binding GO:0032559 46 4.087 1.47E-09
Adenyl nucleotide binding GO:0030554 46 3.856 1.44E-08
Purine nucleoside binding GO:0001883 46 3.789 2.78E-08
Nucleoside binding GO:0001882 46 3.759 5.66E-08
Nucleotide binding GO:0000166 53 3.059 3.25E-07
MAP kinase activity GO:0004707 9 59.748 7.78E-06
Adenylate cyclase activity GO:0004016 8 82.079 1.34E-05
Phosphoprotein phosphatase activity GO:0004721 15 13.329 5.76E-05
Kinase binding GO:0019900 16 10.031 5.56E-04