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Table 3 Antimutagenic activity expressed as mean number of revertants/plate (M) ± standard deviation (SD) and degree of growth inhibition of revertants (%I), in combinations of four Byrsonima species hydroalcoholic extracts with direct and indirect mutagens

From: Mutagenicity and antimutagenicity of six Brazilian Byrsonima species assessed by the Ames test

Mutagens (M) NPDb MMCc AFB1 d B[a]Pe
Strains TA 98 (-S9) TA 102 (-S9) TA 100 (+S9) TA 98 (+S9)
  Treatment (mg/plate) M ± SD and (%I) Treatment (mg/plate) M ± SD and (%I) Treatment (mg/plate) M ± SD and (%I) Treatment (mg/plate) M ± SD and (%I)
B. verbascifolia         
  0 a 18 ± 4 0 a 487 ± 81 0 a 114 ± 6 0 a 36 ± 5
0.013 + M b 483 ± 40** (45) 0.094 + M c 1502 ± 138 (6) 0.125 + M d 213 ± 7*** (85) 0.049 + M e 102 ± 24*** (44)
0.025 + M b 454 ± 60*** (48) 0.188 + M c 1296 ± 24 (19) 0.250 + M d 131 ± 27*** (91) 0.098 + M e 78 ± 6*** (57)
0.050 + M b 550 ± 41** (37) 0.375 + M c 1366 ± 21 (15) 0.500 + M d 125 ± 16*** (91) 0.195 + M e 85 ± 9*** (54)
0.100 + M b 628 ± 138* (28) 0.750 + M c 1380 ± 4 (14) 1.000 + M d 132 ± 13*** (91) 0.390 + M e 41 ± 5*** (78)
0.200 + M b 1001 ± 137 1.500 + M c 1381 ± 58 (14) 2.000 + M d 132 ± 24*** (91) 0.780 + M e 34 ± 7*** (82)
M b 876 ± 30 M c 1601 ± 226 M d 1399 ± 34 M e 184 ± 8
B. correifolia         
  0 a 18 ± 4 0 a 464 ± 48 0 a 104 ± 15 0 a 36 ± 5
0.013 + M b 440 ± 57*** (50) 0.031 + M c 1208 ± 15 (15) 0.008 + M d 353 ± 59*** (60) 0.250 + M e 34 ± 6*** (82)
0.025 + M b 426 ± 2*** (51) 0.063 + M c 1126 ± 66* (20) 0.016 + M d 248 ± 38*** (72) 0.500 + M e 31 ± 6*** (83)
0.050+ M b 497 ± 39*** (43) 0.125 + M c 1152 ± 74* (19) 0.031 + M d 370 ± 49*** (58) 1.000 + M e 32 ± 6*** (82)
0.100+ M b 593 ± 20*** (32) 0.250 + M c 1205 ± 52 (15) 0.063 + M d 180 ± 57*** (80) 2.000 + M e 31 ± 5*** (83)
0.200+ M b 521 ± 61*** (41) 0.500 + M c 1129 ± 146*(20) 0.125 + M d 206 ± 46*** (77) 4.000 + M e 39 ± 3*** (79)
M b 876 ± 30 M c 1414 ± 61 M d 883 ± 80 M e 184 ± 8
B. fagifolia         
  0 a 45 ± 8 0 a 355 ± 36 0 a 94 ± 12 0 a 19 ± 7
0.030 + M b 705 ± 72 (7) 0.010 + M c 1579 ± 94 0.030 + M d 976 ± 38 (8) 0.030 + M e 378 ± 49*** (41)
0.060+ M b 612 ± 43 (19) 0.030 + M c 1395 ± 70 0.060 + M d 915 ± 44 (14) 0.060 + M e 405 ± 51*** (37)
0.120 + M b 623 ± 38 (17) 0.060 + M c 1499 ± 89 0.120 + M d 739 ± 40*** (31) 0.120 + M e 332 ± 35*** (48)
0.250 + M b 593 ± 51 (21) 0.120 + M c 1432 ± 79 0.250 + M d 781 ± 52** (27) 0.250 + M e 268 ± 43*** (58)
0.500 + M b 483 ± 40* (36) 0.250 + M c 1440 ± 65 0.500 + M d 680 ± 36*** (36) 0.500 + M e 157 ± 29*** (76)
M b 755 ± 89 M c 1251 ± 82 M d 1064 ± 101 M e 640 ± 49
B. intermedia         
  0 a 53 ± 12 0 a 317 ± 55 0 a 94 ± 12 0 a 19 ± 7
0.010 + M b 677 ± 67* (24) 0.007 + M c 1593 ± 71 (5) 0.010 + M d 981 ± 61 (8) 0.010 + M e 338 ± 37*** (47)
0.030 + M b 679 ± 61* (24) 0.010 + M c 1584 ± 45 (5) 0.030 + M d 993 ± 32 (7) 0.030 + M e 385 ± 48*** (40)
0.060 + M b 665 ± 82* (26) 0.030 + M c 1504 ± 68 (10) 0.060 + M d 958 ± 20 (10) 0.060 + M e 293 ± 27*** (54)
0.120 + M b 632 ± 54** (29) 0.060 + M c 1443 ± 82 (14) 0.120 + M d 864 ± 39** (19) 0.120 + M e 253 ± 19*** (60)
0.250 + M b 621 ± 42** (30) 0.120 + M c 1409 ± 72 (16) 0.250 + M d 725 ± 23*** (32) 0.250 + M e 148 ± 23*** (77)
M b 893 ± 79 M c 1672 ± 102 M d 1064 ± 101 M e 640 ± 49
  1. aNegative Solvent Control: DMSO, 100 μL/plate; Mutagens (M): b4-nitro-o-phenylenediamine, 10 μg/plate; cMitomycin C, 0.5 μg/plate; dAflatoxin B1, 0.5 μg/plate; eBenzo[a]pyrene, 1 μg/plate. *p < 0.05, **p < 0.01, ***p < 0.0001 (ANOVA).