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Table 1 Biochemical parameters and the renal levels of cytokines in experimental animals at the end of the eight-week treatment

From: Polysaccharides from Liriopes Radix ameliorate streptozotocin-induced type I diabetic nephropathy via regulating NF-κB and p38 MAPK signaling pathways

 

Normal rats

STZ-diabetic rats

 

Vehicle

Vehicle

PSLR 200

PSLR 300

Body weight (BW) (g/rat)

370.39 ± 13.58d

240.99 ± 16.24b

264.25 ± 15.11b,c

307.72 ± 14.72a,c

Kidney weight (KW) (g)

1.29 ± 0.23c

2.43 ± 0.17a

1.85 ± 0.24a

1.52 ± 0.16

KW/BW ratio × 1000

3.48 ± 0.19d

10.08 ± 0.17b

7.00 ± 0.12b,c

4.94 ± 0.11b,c

Plasma glucose (mg/dl)

92.68 ± 8.59d

425.73 ± 18.07b

336.25 ± 14.92b,c

306.92 ± 15.31b,c

HbAlc (%)

4.79 ± 1.03d

14.31 ± 1.26b

11.75 ± 1.18b

10.91 ± 1.21b

Urine volume (ml/day)

9.26 ± 2.43d

28.16 ± 9.13 b

18.21 ± 6.28b,c

15.84 ± 7.31b,c

Urine protein (mg/day)

6.95 ± 2.84d

34.83 ± 5.29b

16.41 ± 4.13a,c

12.27 ± 5.21d

Plasma Cr (μmol/l)

38.50 ± 6.34d

96.29 ± 8.73b

84.10 ± 8.31b

67.92 ± 7.32b,c

BUN (mmol/l)

7.21 ± 1.58c

16.29 ± 2.80a

13.16 ± 2.11a

11.45 ± 2.21a,c

Ccr (ml/min)

3.88 ± 0.89d

1.65 ± 0.54b

2.37 ± 0.68a,c

2.77 ± 0.34d

Plasma AST (U/l)

125.85 ± 10.47d

374.68 ± 17.34b

219.88 ± 18.26b,c

159.57 ± 17.53d

Plasma ALT (U/l)

57.67 ± 7.92d

218.67 ± 17.12b

145.14 ± 15.78b,c

103.42 ± 13.24a,d

Renal IL-6 (pg/mg protein)

54.06 ± 8.46d

159.34 ± 11.38b

126.34 ± 10.28b,c

105.89 ± 10.94b,c

Renal TNF-α (pg/mg protein)

69.19 ± 9.34d

172.91 ± 10.11b

137.12 ± 9.13b,c

109.45 ± 7.51b,c

Renal IL-10 (pg/mg protein)

64.77 ± 4.17d

28.43 ± 4.25b

36.49 ± 3.91b,c

44.64 ± 3.77b,c

  1. STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with 200 mg/kg/day PSLR (PSLR 200), 300 mg/kg/day PSLR (PSLR 300). Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to disperse PSLR. Values (mean ± SD) were obtained for each group of 8 animals. aP < 0.05 and bP < 0.01 compared to the values of vehicle-treated normal rats, respectively. cP < 0.05 and dP < 0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.