Normal rats | STZ-diabetic rats | |||||
---|---|---|---|---|---|---|
Vehicle | Vehicle | Ruscogenin (mg/kg/day) | Rosiglitazone (5 mg/kg/day) | |||
0.3 | 1.0 | 3.0 | ||||
Body weight (BW) (g/rat) | 374.88 ± 17.92d | 214.84 ± 14.95b | 237.3 ± 17.21b | 261.98 ± 18.32b,c | 291.64 ± 16.24b,c | 315.18 ± 18.10a,d |
Plasma glucose (mg/dl) | 92.78 ± 7.32d | 423.12 ± 16.22b | 418.27 ± 15.34b | 412.37 ± 17.41b | 409.87 ± 14.68b | 262.31 ± 13.71b,c |
HbAlc (%) | 4.79 ± 1.03d | 14.32 ± 1.79b | 14.10 ± 1.63b | 13.92 ± 1.84b | 13.85 ± 1.65b | 9.63 ± 1.59b,c |
Kidney weight (KW) (g/rat) | 1.38 ± 0.17d | 2.28 ± 0.15b | 2.07 ± 0.13b | 1.93 ± 0.21b | 1.85 ± 0.19a,c | 1.79 ± 0.18a,d |
KW/BW ratio (%) | 0.37 ± 0.07d | 1.06 ± 0.08b | 0.87 ± 0.09b | 0.74 ± 0.06b,c | 0.62 ± 0.04a,d | 0.57 ± 0.05a,d |
24-h urine volume (ml/day) | 8.96 ± 1.76d | 27.30 ± 2.95b | 21.84 ± 3.11b | 19.65 ± 2.43b,c | 17.65 ± 3.05a,c | 15.34 ± 2.62a,c |
24-h urine protein (mg/day) | 6.60 ± 2.57d | 28.36 ± 3.95b | 24.11 ± 3.25b | 19.85 ± 2.57,c | 14.82 ± 3.29 a,d | 10.26 ± 4.12a,d |
Scr (μmol/l) | 34.07 ± 5.26d | 87.23 ± 7.96b | 70.33 ± 5.83b,c | 69.78 ± 4.92b,c | 62.21 ± 5.61b,c | 56.49 ± 6.92b,c |
BUN (mmol/l) | 6.51 ± 0.82d | 18.85 ± 1.13b | 15.68 ± 1.25b,c | 14.27 ± 1.38b,c | 12.66 ± 0.94b,c | 9.71 ± 1.02a,c |
Ccr (ml/min) | 4.83 ± 0.63d | 1.78 ± 0.71b | 2.14 ± 0.56b | 2.92 ± 0.61b | 3.43 ± 0.59a,c | 3.71 ± 0.74d |