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Table 1 Body and kidney weights, index of renal hypertrophy, and the renal function-related parameters in experimental animals at the end of the eight-week treatment

From: Ruscogenin ameliorates diabetic nephropathy by its anti-inflammatory and anti-fibrotic effects in streptozotocin-induced diabetic rat

  Normal rats   STZ-diabetic rats
  Vehicle Vehicle Ruscogenin (mg/kg/day) Rosiglitazone (5 mg/kg/day)
0.3 1.0 3.0
Body weight (BW) (g/rat) 374.88 ± 17.92d 214.84 ± 14.95b 237.3 ± 17.21b 261.98 ± 18.32b,c 291.64 ± 16.24b,c 315.18 ± 18.10a,d
Plasma glucose (mg/dl) 92.78 ± 7.32d 423.12 ± 16.22b 418.27 ± 15.34b 412.37 ± 17.41b 409.87 ± 14.68b 262.31 ± 13.71b,c
HbAlc (%) 4.79 ± 1.03d 14.32 ± 1.79b 14.10 ± 1.63b 13.92 ± 1.84b 13.85 ± 1.65b 9.63 ± 1.59b,c
Kidney weight (KW) (g/rat) 1.38 ± 0.17d 2.28 ± 0.15b 2.07 ± 0.13b 1.93 ± 0.21b 1.85 ± 0.19a,c 1.79 ± 0.18a,d
KW/BW ratio (%) 0.37 ± 0.07d 1.06 ± 0.08b 0.87 ± 0.09b 0.74 ± 0.06b,c 0.62 ± 0.04a,d 0.57 ± 0.05a,d
24-h urine volume (ml/day) 8.96 ± 1.76d 27.30 ± 2.95b 21.84 ± 3.11b 19.65 ± 2.43b,c 17.65 ± 3.05a,c 15.34 ± 2.62a,c
24-h urine protein (mg/day) 6.60 ± 2.57d 28.36 ± 3.95b 24.11 ± 3.25b 19.85 ± 2.57,c 14.82 ± 3.29 a,d 10.26 ± 4.12a,d
Scr (μmol/l) 34.07 ± 5.26d 87.23 ± 7.96b 70.33 ± 5.83b,c 69.78 ± 4.92b,c 62.21 ± 5.61b,c 56.49 ± 6.92b,c
BUN (mmol/l) 6.51 ± 0.82d 18.85 ± 1.13b 15.68 ± 1.25b,c 14.27 ± 1.38b,c 12.66 ± 0.94b,c 9.71 ± 1.02a,c
Ccr (ml/min) 4.83 ± 0.63d 1.78 ± 0.71b 2.14 ± 0.56b 2.92 ± 0.61b 3.43 ± 0.59a,c 3.71 ± 0.74d
  1. STZ-diabetic rats were dosed by oral gavage once per day for eight weeks with ruscogenin at the indicated dosage, or rosiglitazone. Normal or STZ-diabetic rats receiving vehicle treatment were given the same volume of vehicle (distilled water) used to prepare test medications. Values (mean ± SD) were obtained for each group of 8 animals. aP < 0.05 and bP < 0.01 compared to the values of vehicle-treated normal rats, respectively. cP < 0.05 and dP < 0.01 compared to the values of vehicle-treated STZ-diabetic rats, respectively.