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Table 5 Cytotoxic activity (IC 50 μg/ml) of A. scabra root extracts

From: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells

Extracts Treatment duration (hour) IC50 a(μg/ml) (SIb)
MCF7 SKOV-3 MRC-5
Methanol 24 70.67 ± 5.86 56.67 ± 1.15 44.98 ± 10.59
48 47.67 ± 4.93 34.67 ± 0.58 47.70 ± 8.68
72 64.00 ± 0.00 34.00 ± 4.36 38.94 ± 5.02
Hexane 24 56.00 ± 2.00 33.33 ± 1.15 30.59 ± 0.36
48 33.67 ± 5.03 28.33 ± 3.51 30.71 ± 3.15
72 40.67 ± 1.15 28.00 ± 1.73 29.59 ± 5.98
Chloroform 24 67. 33 ± 5.03 44.00 ± 5.29 30.27 ± 0.33
48 37.33 ± 4.16 37.00 ± 0.58 51.09 ± 10.80
72 42.67 ± 2.31 33.67 ± 3.21 38.39 ± 5.57
Water 24 >100 >100 >100
48 >100 >100 >100
72 >100 >100 >100
Doxorubicinc 24 2.50 ± 0.10 2.50 ± 0.10 >100
48 2.37 ± 0.23 (32.4) 1.77 ± 0.15 (43.4) 76.87 ± 12.64
72 0.39 ± 0.02 (4.3) 1.47 ± 0.15 (1.1) 1.68 ± 0.42
  1. aData are presented as mean ± SD from three independent experiments triplicate for each. Values in bold characters are considered to have cytotoxic activity (IC5020 μg/ml or less); bSelectivity Index (SI); cPositive control.